It has been shown experimentally that the components of the preparation modify the activity of ligand-receptor interaction of endogenous regulators with corresponding receptors: antibodies to morphine (drug component) are modified activity of ligand-receptor interaction of endogenous regulators with opiate receptors; antibodies to histamine - with H1-histamine receptors; antibodies to bradykinin - with bradykinin receptors; while the combined use of components leads to an increase in the antitussive effect.
In addition to the antitussive effect, the complex drug due to its components has anti-inflammatory, anti-edema, antiallergic, spasmolytic (antibodies to histamine, antibodies to bradykinin) and analgesic action (antibodies to morphine).
Complex preparation of Rengalin due to modification of histamine-dependent activation of H1-receptors of bradykinin-dependent activation B1 and B2-receptors selectively reduces the excitability of the cough center of the medulla oblongata, inhibits the central links of the cough reflex. Inhibiting the centers of pain sensitivity in the thalamus, blocks transmission of pain impulses to the cerebral cortex. Inhibits the flow of painful impulse from the periphery due to a decrease in the release of tissue and plasma algogens (histamine, bradykinin, prostaglandins, etc.). Unlike narcotic analgesics does not cause respiratory depression, drug dependence, does not possess narcogenic and hypnotic effects.
It alleviates the manifestations of acute pharyngitis, laryngitis and bronchitis, reducing bronchospasm. It relieves systemic and local symptoms of allergic reactions by influencing the synthesis and release of histamine and bradykinin from mast cells.