Active substanceIsotretinoinIsotretinoin Similar drugsTo uncover AcneCutan® capsules inwards Yadran Galensky Laboratories a.o. Croatia Verocutan capsules inwards VEROPHARM SA Russia Retasol® solution externally RETYNOIDS FNPP, CJSC Russia Retinoic ointment ointment externally RETYNOIDS FNPP, CJSC Russia Roaccutane® capsules inwards Hoffmann-La Roche Ltd. Switzerland Scratches capsules inwards Ranbaxy Laboratories Limited India Dosage form: & nbspOintment for external use. Composition:Active substance: isotretinoin 0.05 or OD Excipients: butyl hydroxytoluene - 0.05 g, butyl hydroxy anisole 0.025 g, emulsion wax 8.0 g, vaseline oil 8.0 g, glycerol (glycerin) 10.0 g, ethanol (ethyl alcohol) 95% -10.0 g, purified water up to 100 g. Description:Homogeneous ointment from light yellow to yellow. Pharmacotherapeutic group:Regeneration of tissue stimulant. ATX: & nbspD.10.B.A.01 Isotretinoin Pharmacodynamics:Isotretinoin is one of the biologically active forms of vitamin A. It inhibits the terminal differentiation of sebocytes and the hyperproliferation of the epithelium of excretory ducts of the sebaceous glands, normalizes the composition of their secretion and facilitates its evacuation. This reduces the production of sebum and reduces the inflammatory reaction around the glands. Ointment has anti-seborrheic, anti-inflammatory, keratolytic action, enhances the regeneration processes in the skin. Indications:Acne vulgaris, seborrheic dermatitis, rosacea, perioral dermatitis. Carefully:Use with caution in chronic liver, kidney, chronic pancreatitis, decompensation of cardiac activity. Pregnancy and lactation:It is not recommended to apply to large areas of the skin during pregnancy, breast-feeding and women planning pregnancy. Dosing and Administration:Ointment is applied a thin layer on the affected skin areas 2 times a day. Duration of treatment is 4-12 weeks. Repeated treatment is possible after consultation with a doctor. Side effects:In the second week of treatment, there may be an exacerbation reaction - the appearance of new rashes, itching, redness and flaking of the skin. With a pronounced reaction, it is recommended to stop the treatment for a few days before it subsides. In some cases, with individual sensitivity in the first - second day of application, spotty-papular rashes, itching and swelling appear. In such cases, the drug should be discontinued. With prolonged use, it is possible to develop symptoms of chronic hypervitaminosis A (cheilitis, conjunctivitis, dryness and peeling of the skin). Overdose:Ointment should not be prescribed to patients receiving other drugs from the retinoid group to reduce the risk of hypervitaminosis A. The effect of the ointment is weakened by the simultaneous local administration of glucocorticosteroids. Interaction:It is not recommended to apply ointment to the skin around the eyes, as well as with severe acute inflammation. Do not apply to mucous membranes. During treatment, avoid exposure to sunlight, use sunscreens if necessary, preventive and therapeutic use of ultraviolet rays and visits to the solarium are not recommended.The drug does not affect the ability to drive and perform work that requires increased concentration. Form release / dosage:Ointment for external use 0.05% and 0.1%. Packaging:Aluminum tubes on 10, 15, 20 and 35 g. The tube together with the instruction for use is placed in a pack of cardboard. Storage conditions:At a temperature of 2 to 8 ° C. Do not allow freezing. Keep out of the reach of children. Shelf life:2 years. Do not use after expiry date. Terms of leave from pharmacies:Without recipe Registration number:P N000556 / 01 Date of registration:29.08.2008 The owner of the registration certificate:RETYNOIDS FNPP, CJSC RETYNOIDS FNPP, CJSC Russia Manufacturer: & nbspRETYNOIDS FNPP, CJSC Russia Information update date: & nbsp21.09.2015 Illustrated instructions × Illustrated instructions Instructions