Active substanceRibonucleaseRibonuclease Similar drugsTo uncover Ribonuclease lyophilizate locally d / inhal. w / m Stomat. SAMSON-MED, LLC Russia Dosage form: & nbspLiofilizate for the preparation of solution for injection and topical application. Composition:In 1 bottle is contained as an active substance: ribonuclease - 10 mg. Description:Lyophilized mass in the form of a tablet, lumps, powder or plates, white or white with a weak yellowish hue of color. Pharmacotherapeutic group:Proteolytic agent ATX: & nbspD.03.B.A Proteolytic enzymes Pharmacodynamics:Enzyme preparation, obtained from the pancreas of cattle. Depolymerizes RNA to acid-soluble mono- and oligopeptides. Liquefies pus, mucus, viscous and thick sputum; has anti-inflammatory effect. Destroying nucleic acids, delays the reproduction of a number of RNA-co containing viruses. Indications:Diseases of the respiratory tract with viscous hard-to-detachable sputum (bronchiectatic disease, lung abscesses, atelectasis of the lung, exudative pleurisy); periodontitis, gingivitis, sores, fistulas, abscesses, trophic ulcers, sinusitis (acute, exacerbation of chronic), otitis media (acute, chronic exacerbation, including perforated in stages), thrombophlebitis; Tick-borne encephalitis (in severe disease,in combination with a specific gamma globulin). Contraindications:Hypersensitivity to the drug. Chronic heart failure II-III stage, respiratory failure, liver failure, pulmonary tuberculosis (open form), hemorrhagic diathesis. Carefully:Empyema pleura tuberculosis etiology (resorption of exudate can contribute to the development of bronchopleural fistula). Pregnancy and lactation:Data on the use of the drug during pregnancy and during lactation are not present. Dosing and Administration:For inhalations use fine-dispersed aerosol -25 mg per procedure (for this, the drug is dissolved in 3-4 ml of 0.9% sodium chloride solution or in 0.5% solution of procaine).Intrapleural - 25-50 mg in 5-10 ml of 0.9% solution of sodium chloride or 0.2% solution of procaine.Endobronchially enter a solution containing 25-50 mg, using a laryngeal syringe or catheter (including bronchoscopy)With parodontosis and gingivitis - 1% solution of the drug in a 0.5% solution of procaine in the form of applications around the tooth neck and cotton swabs in the gingival pockets soaked in the same solution. The duration of the procedure is 30 minutes, daily, for 10 days.When topical application, the wound or ulcerous surface is sprinkled with powder in the amount of 0.025-0.05 g and napkins or tampons moistened with the solution of the preparation in a 0.9% solution of sodium chloride for 2 to 10 days are applied.With sinusitis - 5-10 mg in 3-5 ml of 0.9% sodium chloride solution is injected into the maxillary (maxillary) sinus after puncture and rinsing; when otitis enter into the ear for 0.5-1.0 ml of a 0.1% solution prepared on a 0.9% solution of sodium chloride.After insertion of the sinus and rinse the drum cavity after 30 minutes. 0.9% solution of sodium chloride.The maximum single dose for local and intracavitary administration is 50 mg.Intramuscularly (in / m) injected 5-10 mg in 1 ml of a 0.9% solution of sodium chloride or 0.5% solution of procaine; course of treatment 2-10 injections of 1-2 injections per day.For treatment of tick-borne encephalitis - in / m, 6 times a day, every 4 hours in a single dose of 25-30 mg; children 1-3 years - 5-8 mg (depending on body weight), 4-6 years - 10-14 mg, 7-11 years - 15-18 mg, 12-15 years - 20 mg. The required amount of the drug is dissolved before injection into 2 ml of 0.25 or 0.5% procaine solution. Before the beginning of treatment, a sample is made for sensitivity to the drug: 0.1 ml is injected into the flexor surface of the forearm; in the absence of a local and general reaction, an entire treatment dose is injected in / m after an hour.The drug is discontinued after 2 days after the temperature normalization. Side effects:Allergic reactions, hyperthermia, tachycardia. With intramuscular injection - soreness, hyperemia at the injection site, with inhalation - irritation of the mucous membranes of the upper respiratory tract, hoarseness. Interaction:No data. Effect on the ability to drive transp. cf. and fur:There was no negative impact on the ability to drive vehicles and mechanisms. Form release / dosage:Liofilizate for solution for injection and topical application 10 mg. Packaging:In bottles of 5 ml. 10 bottles together with the instruction for use are placed in a cardboard box. Storage conditions:In the dark place at a temperature of no higher than 25 0C.Keep out of the reach of children. Shelf life:2 years. Do not use after the date shown on the package. Terms of leave from pharmacies:On prescription Registration number:LS-000391 Date of registration:23.04.2010 The owner of the registration certificate:SAMSON-MED, LLC SAMSON-MED, LLC Russia Manufacturer: & nbspSAMSON-MED, LLC Russia Information update date: & nbsp21.08.2015 Illustrated instructions × Illustrated instructions Instructions