Clinical and pharmacological group: & nbsp

Enzymes and antiferments

Included in the formulation
  • Ribonuclease
    lyophilizate locally d / inhal. w / m Stomat. 
    SAMSON-MED, LLC     Russia
  • АТХ:

    D.03.B.A   Proteolytic enzymes

    Pharmacodynamics:

    Enzyme preparation, obtained from the pancreas of cattle. Depolymerizes RNA to acid-soluble mono- and oligonucleotides. Liquefies pus, mucus, viscous and thick sputum. Destroying nucleic acids, delays the reproduction of some RNA-containing viruses.

    Pharmacokinetics:

    Not studied.

    Indications:

    - Diseases of the respiratory tract with viscous hard-to-detachable sputum (bronchiectatic disease, lung abscesses, lung atelectasis, exudative pleurisy);

    - Parodontosis;

    - gingivitis;

    - osteomyelitis;

    - fistulas;

    - abscesses;

    - trophic ulcers;

    - sinusitis (acute and exacerbation of chronic);

    - Otitis (acute and exacerbation of chronic, including in the perforated stage);

    - thrombophlebitis;

    - tick-borne encephalitis (in severe disease, in combination with a specific gamma globulin);

    - Viral meningitis.

    I.A80-A89.A84   Tick-borne viral encephalitis

    I.A80-A89.A87   Viral meningitis

    VIII.H65-H75.H66   Purulent and unspecified otitis media

    IX.I80-I89.I80   Phlebitis and thrombophlebitis

    IX.I80-I89.I83.0   Varicose veins of the lower extremities with ulcer

    X.J00-J06.J01   Acute Sinusitis

    X.J30-J39.J32   Chronic Sinusitis

    X.J40-J47.J47   Bronchoectasia

    X.J85-J86.J85   Abscess of the lung and mediastinum

    X.J85-J86.J86   Pythothrace

    XI.K00-K14.K05   Gingivitis and periodontal disease

    XI.K00-K14.K12   Stomatitis and related lesions

    XIII.M86-M90.M86   Osteomyelitis

    Contraindications:

    hypersensitivity;

    - chronic heart failure II-III stages;

    - respiratory insufficiency;

    - liver failure;

    - tuberculosis (open form);

    bleeding.

    Carefully:

    Empyema of the pleura (tuberculous etiology).

    Pregnancy and lactation:

    Adequate and well-controlled studies in humans and animals have not been conducted. Application is not recommended. There is no information on the penetration into breast milk. Application is not recommended.

    Category FDA recommendations are not defined.

    Dosing and Administration:

    With topical application Sprinkle the wound or ulcer surface with a powder in the amount of 25-50 mg and apply wipes or tampons moistened with the solution of the preparation in a 0.9% solution of sodium chloride.

    For inhalations use a finely dispersed aerosol - 25 mg per 1 procedure (for this, the drug is dissolved in 3-4 ml of 0.9% sodium chloride solution or in 0.5% solution of procaine).

    Endobronchially A solution containing 25-50 mg is administered by means of a laryngeal syringe or catheter.

    Intrapleural - 25-50 mg in 5-10 ml of a 0.9% solution of sodium chloride or 0.2% solution of procaine.

    With sinusitis - 5-10 mg in 3-5 ml of a 0.9% solution of sodium chloride in the maxillary (maxillary) sinus after puncture and rinsing; with otitis media - 0.1% solution (0.5-1 ml) into the external auditory meatus.

    In / m injected 5-10 mg in 1 ml of a 0.9% solution of sodium chloride or 0.5% solution of procaine; course of treatment - 2-10 injections, 1-2 injections per day.

    The maximum single dose for intravenous injection - 10 mg, with local and intracavitary injection - 50 mg.

    For the treatment of tick-borne encephalitis - in / m, 6 times / day, in a single dose - 25-30 mg; children 1-3 years - 5-8 mg (depending on body weight), 4-6 years - 10-14 mg, 7-11 years - 15-18 mg, 12-15 years - 20 mg.

    Side effects:

    Irritation of the mucous membranes of the respiratory tract, allergic reactions.

    Overdose:

    Not described.

    Interaction:

    Not described.

    Special instructions:

    The activity of ribonuclease is determined by the biological method according to the amount of acid-soluble substances released as a result of hydrolysis of RNA under certain conditions. One unit of activity corresponds to 1 mg of the drug.

    The necessary amount of the drug is dissolved before injection into 2 ml of 0.25-0.5% solution of procaine. Before the beginning of treatment, samples for sensitivity to the drug are carried out: 0.1 ml is injected intradermally into the flexor surface of the forearm; Therapy is carried out in the absence of a local and general reaction.

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