Included in the formulation
АТХ:A.11.C.B Combination of vitamins A and D
Pharmacodynamics:The pharmacological action of the product is determined, first of all, by the content of polyunsaturated fatty acids of the omega-3 class (eicosapentaenoic, docosahexaenoic). These acids are structural components of cell membranes, contribute to lowering blood cholesterol, reduce triglycerides as a result of a reduction in the concentration of very low density lipoproteins, reduce platelet aggregation, and improve the rheological properties of the blood.
Pharmacokinetics:During and after absorption in the small intestine of fatty acids of the omega-3 class, there are 3 main ways of their metabolism:
1. Fatty acids are first delivered to the liver, where they are included in various lipoprotein categories and sent to peripheral lipid stocks.
2. Phospholipids of cell membranes are replaced by phospholipids of lipoproteins, after which fatty acids can act as precursors of various eicosanoids.
3. Most fatty acids are oxidized to provide energy needs.
The concentration of omega-3 fatty acids (EPA and DHA) in blood plasma phospholipids corresponds to the concentration of these fatty acids included in the composition of cell membranes.
Indications:Prevention of conditions caused by dyslipidemia (violation of lipid metabolism).
Complex therapy of lipid metabolism disorders, including a diet, statins, antiaggregants.
IV.E70-E90.E78 Disorders of lipoprotein metabolism and other lipidemia
Contraindications:- Chronic cholecystitis and pancreatitis (and periods of their exacerbation).
- Simultaneous use of fibrates, oral anticoagulants.
- In severe injuries, surgical operations (due to the risk of increased bleeding time).
- Pregnancy.
- Lactation period.
- Childhood up to 12 years (for capsules).
- Hypersensitivity to the components of the drug.
Carefully:Hypersensitivity.
Pregnancy and lactation:Contraindicated in pregnancy and lactation.
Category of recommendations for FDA is not defined.
Dosing and Administration:Take inside, 1-2 capsules 3 times a day. The course of application is not less than 1 month.
In the form of oil for children from 3 months - 1/2 teaspoon per day. At the age of 1 year - 1 teaspoon per day. Children from 2 years - 1-2 teaspoons a day; from 3 to 6 years on 1 dessert spoon a day; with 7 years and adults - 1 tablespoon per day.
Side effects:Possible allergic reactions, reduced coagulability, exacerbation of chronic cholecystitis and pancreatitis, diarrhea, the smell of fish from the mouth.
Overdose:Not described.
Treatment is symptomatic.
Interaction:It is not recommended to take patients undergoing treatment in connection with cardiovascular diseases or taking drugs that affect the rate of blood clotting.
Special instructions:Patients who are on anticoagulant therapy during the reception of fish oil should be under constant medical supervision, and if necessary, appropriate correction of the dose of anticoagulant should be carried out.