Fish fat (Fish oil)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceFish oil from cod liverFish oil from cod liver
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  • Fish fat
    capsules inwards 
    MINSKINTERKAPS, UP     Republic of Belarus
  • Fish oil purified for internal use
    butter inwards 
    TULA PHARMACEUTICAL FACTORY, LTD.     Russia
    • Dosage form: & nbspTOthe apsules.
    Composition:For 1 capsule:

    Active substance: fish oil, vitaminized - 500 mg (contains 500 ME Vitamin A, 50 ME Vitamin A D, eicosapentaenoic acid not less than 8%, docosahexaenoic acid not less than 9%, polyunsaturated fatty acids not less than 20%).

    Composition of gelatin capsule shell: gelatin - 136.13 mg, glycerol - 62.92 mg, purified water - 17.6 mg, methyl parahydroxybenzoate - 0.28 mg, propyl parahydroxybenzoate - 0.07 mg.

    Description:

    Capsules soft gelatinous oval, with a seam, elastic, transparent, light yellow color.

    Contents of the capsules - a transparent oily liquid from light yellow to yellow, with a weak specific, non-fragrant odor.

    Pharmacotherapeutic group:vitamin - calcium-phosphorus exchange regulator
    ATX: & nbsp

    A.11.C.B   Combination of vitamins A and D

    Pharmacodynamics:

    Capsules "Fish oil" is a medicinal product of animal origin, the action of which is determined by the properties of its constituent vitamins A and D.

    Vitamin A - fat-soluble vitamin, plays an important role in oxidation-reduction processes, participates in the synthesis of mucopolysaccharides, proteins, lipids.Participates in the formation of visual pigments necessary for normal twilight and color vision; ensures the integrity of epithelial tissues, regulates the growth of bones.

    Vitamin D stimulates absorption of calcium and phosphorus in the intestine, reabsorption of calcium and phosphorus in the kidneys, transport of calcium through the cell membranes, regulates the preservation of bone structure. It also has a positive effect on the development of the immune system, the proliferation and differentiation of cells, the synthesis of lipids and a number of hormones, the functional activity of the cardiovascular system and the gastrointestinal tract, reduces the level of parathyroid hormone in the blood. It is necessary for the normal functioning of parathyroid glands, takes part in the synthesis of adenosine triphosphate.

    Pharmacokinetics:

    Suction

    Retinol is absorbed from the gastrointestinal tract (mainly from the duodenum and jejunum) after emulsification with bile acids. Entered in the microvilli of the intestine retinol is subjected to esterification. The resulting retinyl palmitate binds to specific lipoproteins,penetrates into the lymphatic pathways and enters the liver as part of the chylomicrons, where it is captured by stellate reticuloendotheliocytes, and then by hepatocytes, where the chylomicrons are cleaved, releasing the retinyl palmitate, retinol and retinal and the retinoic acid formed from it. Retinol binds to a specific protein, enters the bloodstream, combines with albumins and is transported to various organs.

    Absorption of Vitamin D occurs in the proximal part of the small intestine, necessarily in the presence of bile. Part of the vitamin D absorbed in the middle parts of the small intestine and a small part - in the ileum. After absorption, cholecalciferol is found in free-form chylomicrons and only partially in the form of an ester. In the blood, most of it is in a bound state with gamma globulins and albumins.

    Distribution

    Retinol is distributed unevenly in the body: the largest amount is in the liver and retina of the eye, the smaller is in the kidneys, heart, lungs, lactating mammary gland, in the adrenal glands. Retinol deposited in the form of retinol palmitate, its reserves are slowly, but constantly updated.In the tissues retinol is localized mainly in the microsomal fraction, mitochondria, lysosomes, in the membranes of cells and organelles.

    Vitamin D in large quantities accumulates in the bones, in less - in the liver, muscles, blood, small intestine, especially long retained in adipose tissue. In small amounts penetrates into breast milk.

    Metabolism and excretion

    Retinol binds to glucuronic acid: β-glucuronate undergoes hepatic circulation and oxidation to retinal and retinoic acid. Retinoic acid is decarboxylated and binds to glucuronic acid, further excreted with bile and feces. The half-life of retinol is very long and is measured from several weeks to several months. Retinoic acid and other water-soluble metabolites are also excreted in urine and feces.

    The main processes of vitamin biotransformation D occur in the skin, liver and kidneys. In the skin, under the influence of ultraviolet irradiation, a vitamin D3 from its predecessors. In the liver, a vitamin D, hydroxylated, turns into 25-hydroxycholecalciferol (25-OH-D3).The latter in the kidneys with the participation of parathyroid hormone passes into the most active metabolite of the vitamin D - calcitriol, or 1,25-dihydroxycholecalciferol (l,25(OH)2-D3). The half-life of the vitamin D from the body is about 19 days. It is excreted by excretion with bile, initially into the intestine (15-30% of the administered dose during the day), where it undergoes enterohepatic circulation (re-absorption). The rest is excreted with feces.

    Indications:

    Prevention of hypovitaminosis A and D.

    Contraindications:

    Hypersensitivity to the components of the drug; idiopathic hypercalcemia, hypercalciuria, acute and chronic liver and kidney disease, chronic pancreatitis, urolithiasis; hypervitaminosis A and D, pulmonary tuberculosis (active form), cholelithiasis, long-term immobilization (large doses), thyrotoxicosis, acute inflammatory skin diseases, sarcoidosis and other granulomatosis, pregnancy, the period of breastfeeding; children under 7 years.

    Carefully:

    Organic heart disease, heart failure II-III stage, peptic ulcer and duodenal ulcer, atherosclerosis, alcoholism, hypothyroidism, elderly age.

    Dosing and Administration:

    Take 1-2 capsules 3 times a day, after eating, washed down with cold or slightly warm water.

    It is recommended to immediately swallow the capsules, squeezed them with plenty of water, do not keep them in the mouth for a long time, tk. gelatin, which is part of the shell, can make the capsule sticky, which will complicate the subsequent ingestion.

    The course of application is not less than 1 month. The duration of the drug is determined by the doctor.

    Side effects:

    When using the drug in recommended doses, side effects are usually not observed.

    Allergic reactions, decrease in blood coagulability are possible.

    Overdose:

    Symptoms of an acute overdose of vitamin A: double vision, dizziness, diarrhea, irritability, osteoporosis, gingival hemorrhage, dryness and ulceration of the oral mucosa, exfoliation of the lips, skin, confusion, increased intracranial pressure.

    Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dryness of the skin, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, fatigue, discomfort, headache, photosensitivity, pollakiuria.nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhoea, portal hypertension, hemolytic anemia, changes in bone radiographs, seizures.

    Symptoms of acute intoxication with vitamin D (early): dryness of the oral mucosa, thirst, constipation or diarrhea, polyuria, anorexia, metallic taste in the mouth, nausea, vomiting, fatigue, weakness, adynamia, hypercalcemia, hypercalciuria, dehydration; (late): pain in the bones, clouding of urine, increased blood pressure, pruritus, photosensitivity of the eyes, congestion hyperemia, arrhythmia, drowsiness, myalgia, nausea, vomiting, pancreatitis, gastralgia, weight loss, rarely - psychosis and mood changes.

    Symptoms of chronic intoxication: calcification of soft tissues, kidneys, lungs, blood vessels, hypertension, renal and chronic heart failure; in children - a growth disorder.

    Treatment: abolition of the drug, a diet low in calcium, the consumption of large quantities of liquid. Symptomatic treatment.The specific antidote is unknown.
    Interaction:

    Vitamin activity D can decrease with its simultaneous use with anticonvulsants or barbiturates.

    With simultaneous use with estrogens, the risk of hypervitaminosis A.

    Vitamin A lowers the anti-inflammatory effect of glucocorticoids.

    Weaken the effect of calcium preparations, benzodiazepines and increase the risk of hypercalcemia.

    Kolestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A.

    Isotretinoin increases the risk of toxic effects.

    Simultaneous use of tetracycline and vitamin A in high doses (50 thousand units or more) increases the risk of developing intracranial hypertension.

    Can reduce the vitamin A stores in the body high doses of vitamin E.

    With hypervitaminosis D it is possible to increase the action of cardiac glycosides and increase the risk of arrhythmia.

    Under the influence of barbiturates (including phenobarbital), phenytoin, primidone, the need for vitamin D can significantly increase.

    Long-term therapy with the drug against the background of simultaneous use of aluminum and magnesium-containing antacids increases the concentration of vitamins A and D in blood.

    Calcitonin, bisphosphonates, isoniazid, rifampicin, plikamycin, glucocorticosteroids reduce the effect of the drug.

    Increases the absorption of phosphorus-containing drugs and the risk of hyperphosphataemia.

    When used simultaneously with sodium fluoride, the interval between the intake should be at least 2 hours; with oral forms of tetracyclines - not less than 3 hours.

    Special instructions:

    The drug "Fish oil" is not recommended to be used simultaneously with other vitamin preparations containing vitamins A and D, to avoid overdose of these vitamins.

    Long-term use in high doses leads to chronic hypervitaminosis. With the preventive use of vitamin A D it is necessary to bear in mind the possibility of an overdose, especially in children.

    In the elderly, the need for a vitamin D can increase.

    One capsule contains 500 ME vitamin A and 50 ME vitamin A D.

    Effect on the ability to drive transp. cf. and fur:

    The use of the drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Capsules, 500 mg.
    Packaging:

    For 10 capsules in a contour mesh package (blister) from a film of polyvinyl chloride grade and foil of aluminum printed lacquered.

    For 5 contour squares (blisters) together with instructions for use, they are placed in a pack of cardboard.

    Storage conditions:

    In a dry, the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-002540
    Date of registration:22.07.2014
    Expiration Date:22.07.2019
    The owner of the registration certificate:MINSKINTERKAPS, UP MINSKINTERKAPS, UP Republic of Belarus
    Manufacturer: & nbsp
    MINSKINTERKAPS, UP Republic of Belarus
    Representation: & nbspMINSKINTERKAPS MINSKINTERKAPS Republic of Belarus
    Information update date: & nbsp26.12.2016
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