Intravenous, intramuscular, intrathecal.
Intravenous administration: for adults and children (over 1 year old) with normal renal function, the daily dose is 1.5-2.5 mg / kg (taking into account that 1 mg of purified polymyxin B is equivalent to 10,000 units of polymyxin B) in 2 administrations at intervals of 12 hours.
The maximum daily dose should not exceed 2.5 mg / kg.
In children younger than 1 year with normal kidney function, if necessary, the daily dose can be increased to 4 mg / kg, which is divided into 2 injections and administered at an interval of 12 hours.
To prepare a solution for intravenous administration to adults, 50 mg of the drug is dissolved in 300-500 ml of 5% dextrose solution and injected at a rate of 60-80 cap / min. In children, the dose of the drug, intended for intravenous administration, is dissolved in 30-100 ml of a 5-10% solution of dextrose.
Intramuscular injection (only with the impossibility of intravenous administration): for adults and children (over 1 year old) with normal renal function, a daily dose of 2.5-3 mg / kg in 3-4 injections every 6-8 hours. In children up to 1 year old with normal renal function, if necessary, the daily dose can be increased to 4 mg / kg, which is divided into 4 injections and administered at an interval of 6 hours.
To prepare a solution for intramuscular injection, 25 mg is dissolved in 1 ml, 50 mg in 2 ml of 1% solution of procaine, water for injection or 0.9% solution of sodium chloride.
Intrathecal administration (is a therapy of choice for meningitis caused by Pseudomonas aeruginosa): adults and children (over 2 years) - 5 mg once a day for 3-4 days, then every other day for 2 weeks after receiving a negative result of bacteriological inoculation and normalization of glucose concentration in the cerebrospinal fluid; children under 2 years - 2 mg once a day for 3-4 days or 2.5 mg once every 2 days. Then in a dose of 2.5 mg every other day for 2 weeks after receiving a negative result of bacteriological inoculation and normalization of glucose concentration in the cerebrospinal fluid.
Before the introduction, the preparation 25 mg is dissolved in 5 ml, 50 mg in 10 ml of 0.9% sodium chloride solution (concentration of the prepared solution 5 mg / ml).
In patients with impaired renal function, the dose of the drug decreases and increases the interval between administrations in accordance with the creatinine clearance:
| Creatinine clearance, ml / min | % of the dose with normal kidney function | Interval between administrations, hour |
| 20-50 | 75-100 | 12 |
| 5-20 | 50 | 12 |
| Less than 5 | 15 | 12 |
Solutions of the drug Sabvixin, prepared with water for injection, 0.9% sodium chloride solution, 5% dextrose solution, 0.5-1% procaine solution, can be stored for 12 hours at room temperature (25 ° C) or for 4 days in the refrigerator (from 2 to 8 ° C).