Sanorin-analgesin (Sanorin-Analergin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAntazolin + NaphazolineAntazolin + Naphazoline
Dosage form: & nbspnasal drops
Composition:Each vial (10 ml) contains:
Active substances:
Naphazoline nitrate is 2.5 mg,
antazolin mesylate - 50 mg.
Excipients:
Boric acid 145 mg,
methylparahydroxybenzoate 10 mg,
disodium edetate - 1 mg,
water up to 10 ml.
Description:Transparent colorless liquid without visible mechanical inclusions.
Pharmacotherapeutic group:Anti-allergic drug combined (H1-histamine receptor blocker + alpha-adrenomimetic).
ATX: & nbsp

S.01.G.A.51   Naphazoline in combination with other drugs

Pharmacodynamics:

Nafazoline refers to alpha2-adrenomimetics, has a rapid, pronounced and prolonged vasoconstrictive effect on the vessels of the mucous membrane of the nasal cavity (reduces swelling, flushing, exudation). Relieves nasal breathing in rhinitis. After 5-7 days there is tolerance. Antazolin - selective blocker H1-histamine receptors, has anti-allergic, anti-edematous and anti-exsudative action.

With topical application, the reduction in edema of the mucous membrane of the nasal cavity and the narrowing of the vessels occur within 10 minutes and persist for 2-6 hours.
Pharmacokinetics:

When topical application is absorbed into the systemic circulation through the mucosa of the nasal cavity. Data on the distribution, metabolism and elimination of the drug Sanorin-Anaerhegine is not available.

Indications:

The drug Sanorin-Anaerhegine is indicated for the treatment of acute rhinitis, especially allergic etiology; rhinorrhea.

Contraindications:Hypersensitivity to the components of the drug; arterial hypertension, severe atherosclerosis, hyperthyroidism, age under 16, pregnancy, lactation period, chronic atrophic rhinitis, diabetes mellitus; tachycardia; simultaneous administration of monoamine oxidase inhibitors (MAO) and up to 14 days after the end of their use.
Carefully:

Pheochromocytoma, simultaneous treatment with drugs that increase blood pressure, use of inhalation anesthesia, which increase the sensitivity of the myocardium to sympathomimetic drugs, including halothane, bronchial asthma, prostatic hyperplasia,ischemic heart disease (angina).

Pregnancy and lactation:The drug Sanorin-Anaalergin should not be used by pregnant women, and nursing mothers. In case of pregnancy, taking the drug should be stopped, in the case of taking the drug during lactation, breastfeeding should be interrupted for the entire period of treatment with the drug Sanorin-Anaerhegine.
Dosing and Administration:

Adults and children over 16 years of age

2-3 drops in each nasal passage 3-4 times a day. Apply for a short time, no more than 1 week, then take a break for several days.

Side effects:

At recommended doses, the drug is usually well tolerated. In rare cases, there may occur such adverse reactions as nausea, tachycardia; headaches, pain, irritability, allergic reactions, rash, increased arterial pressure, reactive hyperemia, swelling of the nasal mucosa, local irritation. With prolonged and frequent use, more than 1 week, - edema and atrophy of the mucous membrane of the nasal cavity.

Overdose:

When an overdose of the drug as a result of systemic action may develop nervousness, lower body temperature, inhibition, drowsiness, bradycardia,sweating, increased blood pressure, which can be replaced by lowering blood pressure.

Treatment: symptomatic.

Interaction:

Nafazoline slows the absorption of local anesthetic drugs (lengthens their action in the conduct of surface anesthesia).

MAO inhibitors increase the risk of development of severe arterial hypertension (release of deposited catecholamines under the action of naphazoline), slow the metabolism of antazoline in the liver - enhance the effect.

Special instructions:

May have a resorptive effect.

With prolonged use, the severity of the vasoconstrictor effect gradually decreases (the phenomenon of tachyphylaxis), it is possible to develop edema of the mucous membrane of the nasal cavity with subsequent atrophy, in this connection it is recommended after 5-7 days of use to take a break for several days.

Form release / dosage:

The drops are nasal.

Packaging:For 10 ml of the drug in glass bottles made of brown glass, equipped with a rubber pipette SANO with a lid of polyethylene and a label. Each bottle is placed in a cardboard box with instructions for use.
Storage conditions:

In the dark place at a temperature of 10 to 25 ° C.

Do not store in the refrigerator and do not freeze.

Keep out of the reach of children!

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription
Registration number:P N015219 / 01-2003
Date of registration:22.10.2008
The owner of the registration certificate:Teva Pharmaceutical Enterprises Co., Ltd.Teva Pharmaceutical Enterprises Co., Ltd. Israel
Manufacturer: & nbsp
Representation: & nbspTeva Teva Israel
Information update date: & nbsp16.02.2011
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