This dosage form of Sunprase is indicated only for intravenous administration.The drug is recommended only in cases where oral administration of pantoprazole is not indicated. As soon as oral therapy becomes available, intravenous administration should be discontinued.
The recommended dose for intravenous administration is the administration of the contents of one vial (40 mg pantoprazole) once a day. Data on intravenous administration can be used for 7-10 days, prolongation of the course of treatment depends on the clinical need.
With prolonged treatment of Zollinger-Ellison syndrome and other pathological hypersecretory states, the recommended daily dose at the beginning of treatment is 80 mg of Sanpras. After this dose may be increased or decreased. If the drug is used in a daily dose of more than 80 mg, the dose should be divided and administered twice a day. Perhaps a temporary increase in the daily dose to 160 mg of Sanpras.
With eradication Helicobacter pylori in combination with antibacterial agents, the recommended daily dose is 80 mg of Sanprasse for 7-10 days, the dose should be divided and administered twice a day.
Patients with impaired hepatic function: with severe violations of liver function, the daily dose should be reduced to 20 mg of pantoprazole. In addition, during treatment with the drug, such patients need regular monitoring of the activity of liver enzymes. In the case of increased activity of hepatic enzymes, treatment should be discontinued.
To elderly patients: there is no need to increase the daily dose of pantoprazole 40 mg, as well as to patients with impaired renal function (including patients on hemodialysis).
During pregnancy and breastfeeding: experience in the use of the drug in this period is limited. In studies of reproductive function in animals, little embryotoxicity was noted in doses exceeding 5 mg / kg. The drug may be used only if the benefit to the mother from the application exceeds the possible risk to the fetus. There are no data on the release of pantoprazole with breast milk. You should stop breastfeeding while taking the drug.
Childhood. There is insufficient data on the use of the drug in children under 18 years of age.
Before the injection, the contents of the vial must be reconstituted with 10 ml of 0.9% sodium chloride solution.
This solution is injected or infused after mixing with 100 ml of 0.9% sodium chloride solution, 5% glucose solution or 10% glucose solution. The pH of the ready-to-use solution should be within 9-10. The duration of administration should be 2-15 minutes. The prepared solution should be used within 3 hours after preparation.