Active substanceFonorucetamFonorucetam
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  • Slim Story Prof
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    VALENTA PHARM, PAO     Russia
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    Life Sainses OHCF     Russia
  • Dosage form: & nbspTfilm-covered abeys.
    Composition:

    1 tablet contains:

    active substance: fonotracetam (phenylpyrazetam) 100.0 mg;

    Excipients: calcium hydrophosphate anhydrous 62.0 mg, giprolose 6.0 mg, microcrystalline cellulose 24.0 mg, sodium carboxymethyl starch type A 6.0 mg, calcium stearate 2.0 mg;

    film sheath Aquarius preferred HSP VRPZ16005 green 6.0 mg (hypromellose 1,500 mg, copovidone 1,350 mg, polydextrose 0,900 mg, macrogol-3,350 0,570 mg, glyceryl caprylcaprate 0.180 mg, titanium dioxide (E 171) 1,350 mg, dye quinoline yellow (E 104) 0.132 mg, dye brilliant blue (E 133) 0.018 mg).

    Description:

    Round biconvex tablets, covered with a film membrane from light green to green, with engraving "F"On one side, on the cross section - the core is white or almost white.

    Pharmacotherapeutic group:nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    Pharmacodynamics:

    Fonotracetam is a nootropic drug,has a pronounced antiamnestic effect, has a direct activating effect on the integrative activity of the brain, promotes memory consolidation, improves concentration of attention and mental activity, facilitates the learning process, increases the speed of information transfer between hemispheres of the brain, increases the resistance of brain tissues to hypoxia and toxic effects, possesses anticonvulsant action and anxiolytic activity, regulates the processes of activation and inhibition of the central nervous system th system (CNS), improves mood.

    Fonturacetam has a positive effect on the metabolic processes and blood circulation of the brain, stimulates redox processes, increases the energy potential of the body through the utilization of glucose, improves regional blood flow in the ischemic areas of the brain. Increases the content of norepinephrine, dopamine and serotonin in the brain, does not affect the level of content γ-aminobutyric acid (GABA), does not bind to either GABAA, nor with GABAAT receptors, does not have a significant effect on the spontaneous bioelectrical activity of the brain.

    Fonotracetam has no effect on respiration and cardiovascular system, shows an unexpressed diuretic effect, has anorexigenic activity in course use.

    The stimulating effect of fonetracetam is manifested in its ability to exert a moderately pronounced effect on motor responses, in increasing physical performance, in pronounced antagonism to the catalepytic action of neuroleptics, and also in weakening the expression of the hypnotics of ethanol and hexenal. The psychostimulatory effect of fonotracetam predominates in the ideator sphere.

    Moderate psychostimulant effect of the drug is combined with anxiolytic activity, improves mood, has some analgesic effect, increasing the threshold of pain sensitivity.

    Adaptogenic action of fonetracetam is manifested in increasing the body's resistance to stress in conditions of excessive mental and physical stress, fatigue, hypokinesia and immobilization, at low temperatures.

    Against the background of reception of fonotracetam, improvement in vision is noted, which is manifested in an increase in acuity, brightness and fields of vision.

    Fonturacetam improves the blood supply of the lower extremities.

    Fonturacetam stimulates the production of antibodies in response to antigen administration, which indicates its immunostimulatory properties, but at the same time it does not promote the development of immediate type hypersensitivity and does not change the allergic inflammatory skin reaction caused by the introduction of a foreign protein.

    With the course of administration of fonuracetam, drug dependence, tolerance, and withdrawal syndrome do not develop.

    The action of fonetracetam appears with a single dose, which is important when the drug is used in extreme conditions.

    Fonotracetam does not have teratogenic, mutagenic, carcinogenic and embryotoxic properties. Toxicity is low, the lethal dose in an acute experiment is 800 mg / kg.

    Pharmacokinetics:

    Fonturacetam is rapidly absorbed, penetrates into various organs and tissues, easily passes through the blood-brain barrier. Absolute bioavailability of fonotracetam when ingested is 100%. The maximum concentration in the blood is reached after 1 hour, the half-life period is 3-5 hours. Fonorucetam It is not metabolized in the body and is excreted from the body in unchanged form. Approximately 40% of fonetracetam is excreted by the kidneys and 60% of the drug is excreted with bile and then.

    Indications:

    - Diseases of the central nervous system of various genesis, especially associated with vascular diseases and disorders of metabolic processes in the brain, intoxication (in particular, in posttraumatic states and chronic cerebrovascular insufficiency), accompanied by deterioration of intellectual and mnestic functions, decreased motor activity;

    - neurotic states, manifested sluggishness, increased exhaustion, decreased psychomotor activity, violation of attention, memory impairment;

    - violation of learning processes;

    - psycho-organic syndromes, manifested by intellectual-mnestic disorders and apatiko-abulic phenomena, as well as flaccid states in schizophrenia;

    - convulsive conditions;

    - obesity (alimentary-constitutional genesis);

    - prevention of hypoxia, increased resistance to stress, correction of functionalthe state of the organism in extreme conditions of professional activity with the purpose of preventing the development of fatigue and increasing mental and physical performance, the correction of daily biorhythm, the inversion of the "sleep-wake" cycle;

    - chronic alcoholism (in order to reduce the phenomena of asthenia, intellectual - mnestic disorders).

    Contraindications:

    Individual intolerance.

    Carefully:

    The preparation of Slim Story is used with caution in patients with severe organic lesions of the liver and kidneys, severe course of arterial hypertension, in patients with atherosclerosis, as well as in patients who have suffered panic attacks, acute psychotic conditions that occur with psychomotor agitation - due to the possibility of worsening anxiety, panic , hallucinations and delusions, as well as in patients prone to allergic reactions to nootropic drugs of the pyrrolidone group.

    Pregnancy and lactation:

    The preparation of Slim Story should not be prescribed during pregnancy and during breastfeeding because of the lack of clinical research data.

    Dosing and Administration:

    The drug Slim Story prof is applied inside, right after eating. The dose of the drug and the duration of treatment should be determined by the doctor. Doses vary depending on the characteristics of the patient's condition.

    The average single dose is 150 mg (100 mg to 250 mg); the average daily dose is 250 mg (from 200 mg to 300 mg). The maximum allowable dose is 750 mg per day. It is recommended to divide the daily dose into 2 doses. The daily dose to 100 mg taken once in the morning, and over 100 mg divided daily dose into two divided doses.

    Duration of treatment can vary from 2 weeks to 3 months. The average duration of treatment is 30 days. If necessary, the course can be repeated in a month.

    To improve performance - 100-200 mg once in the morning, for 2 weeks (for athletes - 3 days).

    The recommended duration of treatment for patients with alimentary-constitutional obesity is 30-60 days at a dose of 100-200 mg once a day (in the morning hours). It is not recommended to take the drug SLIM STORY professional after 15 hours.

    Pediatric Use

    The appointment of SLIM STORY to children is not recommended due to the lack of data on the use of the drug in children.

    Side effects:

    Insomnia (in case of taking the drug later than 15 hours).Some patients in the first 1-3 days of taking the drug may experience psychomotor agitation, hyperemia of the skin, a feeling of heat, an increase in blood pressure.

    Overdose:

    There were no cases of overdose.

    Treatment: symptomatic therapy.

    Interaction:

    Fonotracetam can strengthen the effect of drugs that stimulate the central nervous system, antidepressants and nootropic drugs.

    Special instructions:

    With excessive psychoemotional exhaustion in the background of chronic stress and fatigue, chronic insomnia, a single dose of the drug Slim Story in the first day can cause a sharp need for sleep. Such patients on an outpatient basis should be advised to begin the course of the drug on non-working days.

    Effect on the ability to drive transp. cf. and fur:

    In case of adverse reactions from the CNS during the period of treatment with the drug SLIM STORY, the professional should refrain from performing actions that require an increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:Tablets, film-coated, 100 mg.
    Packaging:

    For 10 tablets in PVC / PVDC / aluminum blister.

    For 3 or 6 blisters together with instructions for use in a cardboard box.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-003559
    Date of registration:11.04.2016
    Date of cancellation:2021-04-11
    The owner of the registration certificate:Teva Pharmaceutical Enterprises Co., Ltd.Teva Pharmaceutical Enterprises Co., Ltd. Israel
    Manufacturer: & nbsp
    Representation: & nbspTeva Teva Israel
    Information update date: & nbsp16.06.2016
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