Strepsils® Intensive (Strepsils® intensive)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceFlurbiprofenFlurbiprofen
Dosage form: & nbsptablets for resorption [honey-lemon]
Composition:

One tablet contains:

active ingredient - flurbiprofen 8.75 mg;

auxiliary components: macrogol 300 5.47 mg, potassium hydroxide 2.19 mg, lemon flavor (502904 A) 3.6 mg, levomentol 2 mg, honey 50.4 mg, sucrose liquid 1407 mg, dextrose 1069 mg. '

Description:

Round tablets from translucent caramel mass from light yellow to light brown color, with the letter S on the 2 sides of the tablet. Air bubbles in the caramel mass and slight unevenness of the edges are allowed. Occurrence of a white touch is possible.


Pharmacotherapeutic group:non-steroidal anti-inflammatory drug (NSAID)
ATX: & nbsp

M.01.A.E.09   Flurbiprofen

Pharmacodynamics:
The mechanism of action of flurbiprofen is associated with inhibition of cyclooxygenase 1 and cyclooxygenase 2 enzymes followed by inhibition of the synthesis of prostaglandins - pain mediators.Has anti-inflammatory and analgesic effect. The drug does not have an antiviral effect. The action of the drug occurs 30 minutes after the beginning of resorption of the tablet in the oral cavity and lasts for 2-3 hours.

Pharmacokinetics:
Absorption is high. Communication with plasma proteins is more than 99%. The maximum concentration in plasma (C max) is reached after 30-40 minutes. Basically, it is metabolized through hydroxylation and excreted by the kidneys. The half-life period (T1 / 2) is 3-6 hours.

Indications:As a symptomatic tool for alleviating pain in the throat with infectious inflammatory diseases of the oral cavity and pharynx.
Contraindications:Hypersensitivity to any of the components of the drug; Stomach ulcer (exacerbation); The bronchial asthma and rhinitis on the background of taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs; children's age (up to 12 years); deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation.
Carefully:
Use with caution in: hyperbilirubinemia (including Gilbert syndrome, Dubin-Joison and Rotor syndrome), chronic circulatory insufficiency, edema,arterial hypertension, hemophilia, hypocoagulation, gastric or duodenal ulcer (in remission, in history), hepatic and / or renal insufficiency, a decrease in blood clotting, oppression of bone marrow hematopoiesis, a decrease in hearing, a pathology of the vestibular apparatus. When prescribing to the elderly, the use of the drug is possible only after consultation with the attending physician.

Dosing and Administration:
. Tablets must be resorbed in the oral cavity until complete dissolution. At resorption, the tablet should be moved all over the oral cavity, to avoid damage to the mucous membrane at the site of resorption. It is recommended that adults and children over 12 years of age take one tablet as needed. Do not consume more than five tablets within 24 hours. Do not take pills for more than 3 days.

Side effects:
Adverse reactions related to the use of Strepfen are mainly related to distortion of taste perception and elements of paresthesia (burning, tingling or tingling). Possible ulceration of the oral mucosa.Unwanted side effects associated with NSAID drugs may occur when taking the drug inside at a dose of 50-100 mg 2-3 times a day (12-30 Strepfen tablets per day).
On the part of the gastrointestinal tract: dyspepsia (nausea, vomiting, heartburn, diarrhea), NSAIDs - gastropatnia, abdominal pain; abnormal liver function; with prolonged use in large doses - ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, hemorrhoidal).
From the cardiovascular system: increased blood pressure, tachycardia, heart failure.
From the hemopoiesis: rarely - anemia (iron deficiency, hemolytic, aplastic), agranulocytosis, leukopenia, thrombocytopenia.
On the part of the nervous system: headache, dizziness, drowsiness or insomnia, asthenia, depression, amnesia, tremor, agitation, rarely - ataxia, paresthesia, impaired consciousness.
From the side of the urinary system: tubulointerstitial nephritis, edematous syndrome, impaired renal function.
Allergic reactions: skin rash, itching, urticaria, bronchospasm, photosensitivity, Quincke's edema, anaphylactic shock.
Other: hearing loss, tinnitus, increased sweating.

Overdose:
Symptoms of an overdose of flurbiprofen can be manifested in the form: when taken 1 g - drowsiness, more than 1.5 g - excitation, 2.5-4 g-nausea, headache, dizziness, epigastric pain, diplopia, miosis, hypotension, more than 4 g- up to a coma. In case of an overdose, the drug should be stopped, treatment: symptomatic.

Interaction:
. Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. Reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants (increases the risk of bleeding), antiplatelet agents, fibrinolytics, side effects of mineral and glucocorticosteroids, estrogens; reduces the effectiveness of antihypertensive and diuretics; enhances the hypoglycemic effect of sulfonylurea derivatives. Increases the concentration in the blood of lithium preparations, methotrexate.

Special instructions:
. Patients with diabetes should consider that the tablet contains about 2.5 g of sugar.
In the case of a combination of pain in the throat with a significant increase in body temperature, taking the drug may be recommended only by a doctor.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test. If there is a high fever, headache, or other undesirable phenomena, you should consult a doctor.
Do not exceed the dose specified in the instructions.
Form release / dosage:Tablets for resorption of honey-lemon
Packaging:8 tablets per blister (PVC / PVDC / Aluminum). For 1, 2 or 3 blisters are placed in a cardboard box together with instructions for use
Storage conditions:
Store in a dry place at a temperature of no higher than 25 ° C. Keep out of the reach of children!

Shelf life:
3 years.
Do not use after the expiration date. Conditions of leave from pharmacies
Terms of leave from pharmacies:On prescription
Registration number:LSR-000884/09
Date of registration:09.02.2009
The owner of the registration certificate:Rekitt Benckiser Helsar International Ltd.Rekitt Benckiser Helsar International Ltd. United Kingdom
Manufacturer: & nbsp
Representation: & nbspRekitt Benckiser Halskar LLCRekitt Benckiser Halskar LLC
Information update date: & nbsp22.10.2015
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