Intramuscularly.
The contents of the vial are dissolved in sterile water for injection or in a 0.9% solution of sodium chloride or in a 0.25-0.5% solution of procaine (Novocaine) at a rate of 4 ml of solvent per gram of streptomycin. The solution is prepared immediately prior to administration.
Adults: single dose for intramuscular injection - 0.5-1 g, daily - 1-
2 The maximum daily dose of streptomycin for an adult is 2 g. With poor tolerability, patients with a body weight of less than 50 kg, and those over 60 years of age - a daily dose of 750 mg.
Children: at the age of 3 months - in a dose of 10 mg / kg / day, at the age of 3 to 6 months - 15 mg / kg / day, from 6 months to 2 years - 20 mg / kg / day, for children up to 13 years and adolescents - 15-20 mg / kg / day, but not more than 500 mg / day - for children under 13 years and 1 g / day for adolescents.
Maximum doses of streptomycin for children of different ages:
2-4 years - single dose - 150 mg, daily - 300 mg;
5-6 years - single dose - 175 mg, daily - 350 mg;
7-9 years - single dose - 200 mg, daily - 400 mg;
9-14 years - single dose - 250 mg, daily - 500 mg;
over 14 years - single 500 mg, daily - 1 g.
Tuberculosis of the lungs and other organs - a daily dose of 15 mg / kg (but not more than 1 g) is administered 1 time per day, with poor tolerance - in 2 divided doses; duration of treatment
3 month and more (in parallel with taking other antituberculosis drugs).
Bacterial endocarditis:
streptococcal etiology (caused by Streptococcus spp., sensitive to penicillin) -
streptomycin is administered in combination with benzylpenicillin for 2 weeks: in the first week - 1 g 2 times a day; during the second week - 500 mg 2 times a day; patients older than 60 years - 500 mg twice a day for 2 weeks;
enterococcal etiology -
streptomycin is administered in combination with benzylpenicillin for 6 weeks: in the first 2 weeks - 1 g 2 times a day; for the next four weeks - 500 mg twice a day (the duration of treatment can be reduced with ototoxicity phenomena).
Tularemia - 0.5-1 g 2 times a day for 7-14 days until the 5th-7th day of absence of febrile temperature.
Plague, brucellosis - 1 g 2 times a day for at least 7-10 days.
With a venereal granuloma,acute bacterial intestinal infections and urinary tract infections - a daily dose is divided into 2-4 of administration, the duration of the course - a minimum of 10 days (not to exceed 14 days).
With renal failure, the daily dose of streptomycin should be reduced. In case of creatinine clearance from 50 to 60 ml / min, the dose should not exceed 500 mg / day; when creatinine clearance is from 40 to 50 ml / min - no more than 400 mg / day.
For the patients with arterial hypertension and ischemic heart disease initial dose of 250 mg / day, the dosage is increased with good tolerability.