Active substanceCinnarizineCinnarizine
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  • Dosage form: & nbspPills.
    Composition:

    Composition in 1 tablet:

    active substance: cinnarizine 25 mg;

    Excipients: silicon dioxide colloid 1.25 mg, potato starch 1.67 mg, magnesium stearate 2.5 mg, povidone 2.5 mg, talc 6.25 mg, corn starch 35.83 mg, lactose monohydrate 175 mg.

    Description:White or almost white round flat tablets with a bevel, practically odorless, with engraving "STUGERON" on one side and risky on the other.
    Pharmacotherapeutic group:The blocker of "slow" calcium channels.
    ATX: & nbsp

    N.07.C.A.02   Cinnarizine

    Pharmacodynamics:

    Selective blocker slow calcium channels, reduces the entry of calcium ions into cells and reduces their content in the depot of the plasmolemma, reduces the tone of the smooth muscles of arterioles, enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, reduces their response to nutrients (adrenaline, norepinephrine, dopamine, angiotensin, vasopressin, serotonin). It has a vasodilating effect (especially with respect to cerebral vessels). The blockade of calcium intake into cells is tissue selective, so the drug has no significant effect on blood pressure and heart rate. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system. The drug prevents the appearance or dips already developed dizziness. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces the viscosity of the blood, improves microcirculation. Increases the resistance of cells and tissues to hypoxia.

    Pharmacokinetics:

    The drug is resorbed in the stomach and intestines. The maximum concentration of the drug in the blood plasma after oral administration after 1-3 hours. The connection of cinnarizine with plasma proteins is 91%. It is completely metabolized in the liver (via glucuronation). The half-life is 4 hours. It is excreted in the form of metabolites: 1/3 - kidney and 2/3 - intestine.

    Indications:

    Adults

    Treatment of cerebrovascular origin symptoms (dizziness, tinnitus, headache vascular genesis, irritability, impaired memory and concentration), vestibular disorders (including Meniere's disease, vertigo, tinnitus, nystagmus, nausea and vomiting, labyrinthine origin) , prevention kinetoses ( "road sickness" - sea and air sickness), migraine (prevention of attacks); peripheral circulatory disorders ( "intermittent" claudication, Raynaud disease, diabetic angiopathy, thrombophlebitis, trophic disorders (including trophic and varicose ulcers), acrocyanosis, paresthesias, cramps and night coldness of the extremities).

    Children over 5 years

    Prevention of kinetosis ("road disease" - sea and air sickness).
    Contraindications:

    Hypersensitivity, pregnancy, lactation.

    Age to 5 years (effectiveness and safety not established).

    Carefully:With Parkinson's disease.
    Pregnancy and lactation:

    Although preclinical studies have not shown teratogenic effects of cinnarizine, the drug can be prescribed during pregnancy only if the expected benefit to the mother exceeds the potential risk to the fetus.

    There is no data on the penetration of cinnarizine in breast milk, so during the reception of the drug, breast-feeding should be discontinued.

    Dosing and Administration:

    Inside, after eating.

    If there is a violation of the blood circulation of the brain - 25-50 mg (1-2 tablets) three times a day; when peripheral circulation is disturbed - 50-75 mg (2-3 tablets) three times a day; with vestibular disorders - 25 mg three times a day; with kinetosis ("road" disease): adults - 25 mg for half an hour before the road (if necessary, repeated intake of 25 mg after 6 hours). The maximum dose of the drug should not exceed 225 mg (9 tablets) per day. The dose for children from 5 to 12 years is ½ the dose recommended to adults, the dose for children over 12 years of age corresponds to the dose recommended for adult patients.

    With high sensitivity to the drug, treatment starts with ½ dose, increasing it gradually.The course of treatment is from several weeks to several months.

    Side effects:

    From the nervous system: drowsiness, fatigue, headache, extrapyramidal disorders (tremor of limbs and increased muscle tone, hypokinesia in elderly patients with long-term treatment, in such cases, treatment should be discontinued), depression.

    From the digestive system: dry mouth, epigastric pain, dyspepsia, cholestatic jaundice (extremely rare).

    From the skin: sweating, development of lupus-like syndrome, red flat lichen (extremely rare), skin rash.

    Other: Allergic reactions, weight gain.

    Overdose:

    The maximum recommended dose should not exceed 225 mg (9 tablets) per day. In case of overdose there is no specific antidote, it is necessary to do a gastric lavage and take Activated carbon.

    Treatment is symptomatic.

    Interaction:

    Strengthens the effect of alcohol and sedatives, tricyclic antidepressants. With simultaneous application with nootropic, antihypertensive and vasodilating agents, enhances their effect,and with simultaneous use with drugs prescribed for arterial hypotension - reduces their effect.

    Special instructions:

    Stugeron® can cause drowsiness, especially at the beginning of the course of treatment, so you should refrain from drinking alcohol and take care when sharing with drugs that depress the central nervous system.

    In connection with the presence of antihistamine effect, cinnarizine can affect the result of the anti-doping control of athletes (false positive result), and can also neutralize positive reactions in conducting skin diagnostic tests (4 days before the study treatment should be canceled).

    With long-term use of the drug, a control examination of the liver, kidney function, and clinical analysis of peripheral blood is recommended. Patients suffering from Parkinson's disease, cinnarizine should be assigned only in cases where the benefits from his appointment exceed the possible risk of deterioration.

    Patients with such rare hereditary disorders as galactose intolerance, lactase deficiency or glucose / galactose malabsorption syndrome should not be taken cinnarizine, since the preparation contains 175 mg of lactose monohydrate.

    Effect on the ability to drive transp. cf. and fur:

    Since taking the drug can cause drowsiness, especially at the beginning of treatment, you should refrain from driving the car and potentially dangerous activities requiring increased concentration of attention and psychomotor reactions.

    Form release / dosage:

    Tablets, 25 mg.

    Packaging:For 25 tablets in a blister of PVC and aluminum foil. Two blisters in a cardboard box with instructions for use.
    Storage conditions:

    At a temperature of 15-30 ° C, out of reach of children.

    Shelf life:

    5 years.

    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:П N012845 / 01
    Date of registration:17.12.2010
    The owner of the registration certificate:GEDEON RICHTER, OJSC GEDEON RICHTER, OJSC Hungary
    Manufacturer: & nbsp
    Representation: & nbspGEDEON RICHTER OJSC GEDEON RICHTER OJSC Hungary
    Information update date: & nbsp14.10.2015
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