Sulfalen (Sulfalen)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSulfadimidineSulfadimidine
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  • Sulfalen
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    OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC     Russia
    • Dosage form: & nbspTablet.
    Composition:
    Active substances: sulfalene - 0.2 g
    auxiliary substances: potato starch, magnesium stearate, polyvinylpyrrolidone.
    Description:Tablets are white or white with a yellowish tint of color, flat-cylindrical shape.
    Pharmacotherapeutic group:Antimicrobial agent, sulfonamide.
    ATX: & nbsp

    J.01.E.B   Sulfonilamides of short action

    Pharmacodynamics:
    The drug has antimicrobial activity, has a bacteriostatic effect. It blocks the utilization of para-aminobenzoic acid by microorganisms and the synthesis of folate. It inhibits the multiplication of gram-positive and gram-negative microorganisms (including anaerobes, pneumococci, streptococci, staphylococci).
    Sulfalene does not act on strains of bacteria resistant to sulfonamides.
    Pharmacokinetics:After oral intake quickly absorbed from the gastrointestinal tract, the maximum concentration of the drug in the blood is detected in 4-6 hours. To a lesser extent than other long-acting and ultra-long-acting sulfonamides, it binds to plasma proteins, which ensures its high concentration in the blood in a free active form . It penetrates well into body fluids and tissues.In high concentrations found in bile. Long circulates in the blood. The half-life period averages 65 hours. 60% of the administered dose is excreted within 9 days. Slow excretion from the body is due to intensive reabsorption in the renal tubules. The drug is excreted in the form of metabolites, mainly with urine.
    Indications:
    Infections (caused by microorganisms sensitive to sulfanilamides):
    - respiratory organs - bronchitis, pneumonia;
    - bile ducts - cholecystitis, cholangitis;
    - urinary tracts - pyelitis, cystitis, urethritis, etc .;
    - purulent infections of various locations - wound infection, abscesses, mastitis, osteomyelitis, otitis, sinusitis.
    Contraindications:Intolerance to sulfonamides, the presence of agranulocytosis, hemolytic anemia, drug fever, severe dermatitis, hepatitis, chronic renal failure with azotemia, pregnancy, breast-feeding, deficiency of glucose-6-phosphate dehydrogenase.
    Dosing and Administration:Inside, 30 minutes before meals, daily or 1 time in 7-10 days. Daily appoint with acute rapid infection (1 day adults -1 g, then - 0.2 g / day); 1 time per 7-10 days (in a single dose - 2 g) with chronic, long-term infections within 1-1.5 months.
    Side effects:Allergic reactions, headache, dyspepsia, drug fever, leukopenia, agranulocytosis, crystalluria.
    Interaction:
    Phenytoin (a drug used in the treatment of epilepsy) - increases the risk of developing toxic reactions.
    Methotrexate and other folic acid antagonists increase the risk of developing a deficiency of folic acid.
    Metoksalen (used in the treatment of psoriasis) promotes the development of photosensitization. The effect of sulfalene is enhanced when combined with diaminopyrimidine derivatives (trimethoprim, tetroxoprim, pyrimethamine).
    With the simultaneous use of sulfalene with hexamethylenetetramine or with preparations that increase the formation of uric acid (ammonium chloride), insoluble compounds may appear in the form of concrements in the renal pelvis.
    Special instructions:
    Be careful when appointing patients with diseases of the hematopoietic system, with cardiac decompensation, with liver diseases and renal dysfunction. In such cases, treatment is conducted under the control of urine and blood tests.
    It is recommended to drink abundantly in order to prevent the loss of crystals in the kidneys.In patients with impaired renal excretory function, the treatment is performed under the control of urine and blood tests.
    Form release / dosage:Tablets 200 mg
    Packaging:For 10 tablets per contour cell pack together with instructions for medical use; By 1, 2, 3, 4, 5 contour mesh packages in a pack of cardboard.
    Storage conditions:List B. In a dry and inaccessible place for children.
    Shelf life:
    5 years.
    Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002425 / 01-2003
    Date of registration:07.08.2008
    The owner of the registration certificate:OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp28.08.2015
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