Tagera (Tagera)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSecnidazoleSecnidazole
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  • Tagera
    pills inwards 
    Unikem Laboratories Ltd.     India
    • Dosage form: & nbspfilm coated tablets
    Composition:
    : Each tablet, film-coated, contains: active substance: secnidazole -1g.
    Excipients: microcrystalline cellulose, corn starch, sodium carboxymethyl starch, gelatin, silicon dioxide colloid, magnesium stearate, hypromellose, macrogol - 6000, titanium dioxide.

    Description:: white capsule-like tablets coated with a film sheath with a risk on one side
    Pharmacotherapeutic group:antimicrobial and antiprotozoal agent
    ATX: & nbsp

    J.01.X.X   Other antibacterial drugs

    J.01.X   Other antibacterial drugs

    Pharmacodynamics:
    Synthetic derivative of nitroimidazole. Antibacterial, antiprotozoal. Has a bactericidal effect against most anaerobic bacteria and many protozoa. Interacts with the DNA of microbial cells, breaks its spiral structure, causes rupture of threads and suppresses the synthesis of nucleic acids; Reduces reduction processes.
    Has an amebicidal activity against Entamoeba histolytica.
    Also active against Giardia lamblia and Trichomonas vaginalis

    Pharmacokinetics:
    After ingestion, well (about 80%) is absorbed.After a dose of 2 g of seksnidazole is administered orally, the maximum serum concentration is reached by the third hour. The half-life in plasma is approximately 25 hours. The drug is withdrawn slowly, mainly with urine (approximately 50% of the administered dose is allocated for 120 hours). Secnidazole penetrates the placental barrier and is excreted in the mother's milk.

    Indications:
    Urethritis and vaginitis caused by Trichomonas vaginalis;
    Amoebiasis of the intestine;
    Liver amebiasis;
    Giardiasis.

    Contraindications:
    Hypersensitivity to imidazole derivatives or to any ingredient of this drug.
    Lactation.
    Organic diseases of the central nervous system, blood diseases (including in the anamnesis).
    Children up to 3 years (for this dosage form and children weighing less than 16 kg).

    Pregnancy and lactation:
    Pregnancy
    The experience accumulated to date is not convincing enough to assess the possible fetotoxic effect of seksidazole and the action aimed at the formation of malformations of the fetus when it is used during pregnancy. Therefore, as a precautionary measure, it is better not to appoint secnidazole during pregnancy.
    Lactation
    It has been established that imidazole derivatives are excreted in breast milk, cases of candidiasis of the oral and anal mucosa were recorded, as well as cases of diarrhea in infants who were breastfed in mothers who received imidazole derivatives (but not secnidazole). Therefore, in such cases, newborns should be under the supervision of a doctor, or during the period of treatment should be abandoned breastfeeding.

    Dosing and Administration:
    The drug Tager is used according to the doctor's prescription in order to avoid complications.
    Inside, before eating, squeezed with a little water or mixing with semi-liquid food.
    Urethritis and vaginitis caused by Trichomonas vaginalis:
    Adults: single intake of 2 g immediately before meals.
    Intestinal amebiasis:
    Acute amoebiasis with severe symptoms (histolytica form)
    Adults: single intake of 2 g immediately before meals,
    Children: a single dose of 30 mg / kg / day (duration of treatment is only one day).
    Amoebiasis without clinical symptoms (forms of minuta and cystic): the same daily dose, but is taken within 3 days.
    Hepatic amebiasis:
    Adults: 1.5 grams per day, for one or more doses, taken immediately before meals, for 5 days. Children: at 30 mg / kg / day, for one or more doses, take
    immediately before meals, for 5 days.
    Note: In hepatic amoebiasis in the phase of suppuration, seksidazole should be taken
    combine with the removal of pus by drainage or with the removal of abscesses.
    Giardiasis:
    Children: a single dose of 30 mg / kg / day (duration of treatment is only one day).

    Side effects:
    Possible side effects noted when taking imidazole derivatives:
    most often: disorders of the gastrointestinal tract, such as pain in the stomach, metallic taste in the mouth, glossitis, stomatitis,
    hives,
    moderate leukopenia (after the end of the drug, the number of white blood cells returns to normal),
    rarely: dizziness, impaired coordination of movements, ataxia, paresthesia, peripheral neuropathy.
    With the administration of seknidazole, until now, only rarely have
    digestive disorders (nausea, vomiting, gastralgia).

    Overdose:
    In case of suspected overdose, symptomatic and supportive treatment should be performed. The drug should be discontinued, it is necessary to clean the stomach, take Activated carbon, immediately consult a doctor.

    Interaction:
    Combinations to Avoid:
    Disulfiram: psychotic reactions, confusion;
    Alcohol: an antagonistic reaction ("hot flushes" to the face, vomiting, tachycardia).
    Do not consume alcoholic beverages or medicines containing alcohol.
    Combinations that require caution
    Anticoagulants for oral administration (eg, warfarin): potentiation
    anticoagulant action and an increased risk of bleeding due to decreased hepatic catabolism of the anticoagulant. In such cases, it is recommended that prothrombin time be monitored more often and that the INR (international normalized ratio) be monitored and, if necessary, the oral anticoagulant dose is adjusted throughout the course of therapy with seksnidazole, and also during
    8 days after the end of therapy.

    Special instructions:
    During therapy with seksnidazole, it is not recommended to drink alcoholic beverages.
    Avoid the use of this drug in patients with a history of blood disease.
    Long-term use is desirable under the control of the blood formula. With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.
    The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.

    Form release / dosage:
    Tablets, film-coated 1 g:
    Packaging:
    2 tablets in a blister of PVC and aluminum foil. One blister along with the instructions for use are placed in a cardboard box. For 10 packs are placed in a cardboard box.

    Storage conditions:
    At a temperature of no higher than 25 ° C in a dry, dark place. Keep out of the reach of children.

    Shelf life:
    3 years
    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-006457/09
    Date of registration:13.08.2009
    The owner of the registration certificate:Unikem Laboratories Ltd.Unikem Laboratories Ltd. India
    Manufacturer: & nbsp
    Information update date: & nbsp15.09.2015
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