The frequency of this or that side effect is determined by the following table:
| Frequency | The appearance of side effects |
| Often: | In 1 - 10 patients out of 100 |
| Sometimes: | Less than 1 patient out of 100 |
| Rarely: | Less than 1 patient out of 1000 |
| Rarely: | Less than 1 patient out of 10,000 |
| In some cases: | less than 0.01% |
Allergic reactions
Sometimes: itching and redness of the skin.
Rarely: hypersensitivity reactions with such symptoms as hives, bronchospasm, severe choking.
Rarely: swelling of the skin and mucous membranes, sudden drop in blood pressure and anaphylactic shock; photosensitivity (see "Special instructions"); allergic pneumonitis; vasculitis.
In some cases: malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), exudative erythema multiforme. Common hypersensitivity reactions can sometimes be preceded by lighter skin reactions. The above reactions may develop after the first dose in a few minutes or hours after the administration of the drug.
From the gastrointestinal tract and metabolism
Often: nausea, diarrhea.
Sometimes: loss of appetite, vomiting, abdominal pain.
Rarely: stool with an admixture of blood, which in very rare cases can be a sign of inflammation of the intestine and even pseudomembranous colitis (see "Special instructions"), dysbacteriosis.
Rarely: hypoglycemia (possible signs of hypoglycemia: "wolfish" appetite, nervousness, perspiration, trembling).
The experience of using other quinolones indicates that they are capable of causing an exacerbation of porphyria in patients already suffering from this disease. A similar effect is not excluded when using the drug Tanflomed.
From the nervous system
Sometimes: headache, weakness, dizziness and / or numbness, drowsiness, sleep disturbance (including insomnia).
Rarely: depression, anxiety, hallucinations, paresthesia, tremor, psychomotor agitation, confusion, fear, epileptic seizures, anxiety.
Rarely: visual and hearing impairments, violation of taste sensitivity and smell, reduction of tactile sensitivity.
From the side of the cardiovascular system
Rarely: increased heart rate (heart rate), increased heart rate, lower blood pressure.
Rarely: cardiovascular collapse.
In some cases: interval lengthening Q-T.
From the side of the musculoskeletal system
Rarely: affections of tendons (including tendonitis), arthralgia, myalgia.
Rarely: rupture of tendons (eg, Achilles tendon); this side effect can be observed within 48 hours after the start of treatment and can be bilateral (see "Special instructions"); Muscle weakness, which is of particular importance for patients suffering from myasthenia gravis.
In some cases: muscle damage (rhabdomyolysis).
From the liver and kidneys
Often: increased activity of liver enzymes (alanine aminotransferase and aspartate aminotransferase).
Rarely: hyperbilirubinemia, hypercreatininaemia.
Rarely: hepatitis; acute renal failure, interstitial nephritis.
From the blood and organs of hematopoiesis
Sometimes: an increase in the number of eosinophils, a decrease in the number of leukocytes.
Rarely: neutropenia; thrombocytopenia, which can be accompanied by hemorrhages and increased bleeding.
Rarely: agranulocytosis and the development of severe infections.
In some cases: hemolytic anemia; pancytopenia.
Other
Sometimes: general weakness (asthenia).
Rarely: fever, development of superinfection.