The following undesirable phenomena noted with the use of Temozolomide are distributed according to the frequency of occurrence in accordance with the following gradation: very often (> = 10%), often (> = 1%, <10%), infrequently (> = 0.1%, <1 %), rarely (> = 0.01%, <0.1%) and very rarely (<0.01%).
On the part of the hematopoiesis system: often - thrombocytopenia, neutropenia, lymphopenia; infrequently - pancytopenia, leukopenia, anemia, febrile neutropenia. Oppression of the bone marrow developed usually during the first few cycles of treatment, with a maximum between 21 and 28 days; recovery occurred, usually within 1-2 weeks. No evidence of cumulative myelosuppression was noted.
From the digestive system: very often - nausea, vomiting, anorexia, constipation; often - diarrhea, abdominal pain, indigestion, taste distortion, dysphagia, stomatitis, dry mouth; infrequently - flatulence, gastroenteritis.
From the nervous system: very often - headache, convulsions; often - drowsiness / insomnia, dizziness, paresthesia, asthenia, imbalance, confusion, memory impairment, speech disorder, tremor, neuropathy, anxiety, depression, emotional lability; infrequently - hallucinations, amnesia, gait disturbance, hyperesthesia, hypoesthesia.
From the cardiovascular system: often - peripheral edema, hemorrhage, deep vein thrombosis; infrequently - a feeling of palpitations, arterial hypertension, cerebral hemorrhage, embolism of the pulmonary artery.
From the respiratory system; often - cough, shortness of breath; infrequently - sinusitis, bronchitis. From the genitourinary system: frequent - frequent urination; infrequently, impotence, dysuria, amenorrhea, menorrhagia, vaginal bleeding, vaginitis. Dermatological reactions: very often - alopecia, rash; often - skin itching, dryness, skin, erythema, dermatitis, petechiae; infrequently - a violation of pigmentation, photosensitivity, increased sweating; very rarely - hives, exanthema, erythroderma, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome.
From the musculoskeletal system: often - arthralgia, muscle weakness, myalgia; infrequently - a pain in the back.
From the side of the organ of vision: often - blurred vision, diplopia, narrowing of the fields of vision; infrequently - pain in the eye, dry eyes, decreased visual acuity.
From the organ of hearing: often - hearing impairment, ringing in the ears; infrequently - pain in the ear.
From the endocrine system: infrequently - Cushingoid.
From the immune system: very rarely - allergic reactions, including anaphylaxis.
From the laboratory indicators: often - hyperglycemia, increased activity of alanine aminotransferase (ALT); infrequently - hypokalemia, increased activity of aspartate aminotransferase (ACT), alkaline phosphatase and gamma-glutamyl transferase Other: very often - increased fatigue; often - weight loss, increased body temperature, general malaise; infrequently - weight gain, fever ("hot flashes"), chills, flu-like syndrome; rarely - the adherence of opportunistic infections, including pneumonia, caused by Pneumocystis carinii; very rarely observed the development of myelodysplastic syndrome and secondary malignant processes, including leukemia, as well as the development of prolonged pancytopenia with a risk of developing aplastic anemia.