Active substanceLidocaine + Cetylpyridinium chlorideLidocaine + Cetylpyridinium chloride
Dosage form: & nbsp
Tablets for resorption (menthol).

Composition:

Each tablet contains:

Active substances: cetylpyridinium chloride 2.0 mg, lidocaine hydrochloride 1.0 mg.

Excipients: peppermint leaves 0.5 mg, peppermint Shimmel leaves oil 0.5 mg, levomentol 6.0 mg, acesulfame potassium 6.0 mg, starch corn 55.0 mg, citric acid monohydrate 5.0 mg, macrogol - 6000 25.0 mg, microcrystalline cellulose (Avicel PH-105) 20.0 mg, magnesium stearate 2.0 mg, sorbitol (Karion 3140) 1107.0 mg.

Description:
White rectangular tablets with bevelled edges with a smell of menthol.

Pharmacotherapeutic group:Antiseptic + local anesthetic.
ATX: & nbsp

R.02   Drugs for the treatment of throat diseases

Pharmacodynamics:Cetylpyridinium chloride - antiseptic from the group of quaternary ammonium compounds, has bactericidal activity against Gram-positive and to a lesser extent Gram-negative bacteria. It changes the permeability of the cytoplasmic membrane of bacteria, disrupts the internal oxidative mechanisms of respiration of bacteria, which leads to their death. Cetylpyridinium chloride has antifungal and antiviral activity against enveloped viruses.
Lidocaine hydrochloride is a local anesthetic from the group of amides, and in inflammatory processes it relieves pain in the throat when swallowing. Lidocaine breaks the permeability of the cell membrane for sodium ions, which leads to anesthesia as a result of blockade of conduction of nerve impulses.
Pharmacokinetics:
Cetylpyridinium chloride is practically not absorbed through the mucosa of the oral cavity.
Lidocaine hydrochloride is poorly absorbed through the mucous membrane of the oral cavity. When ingested, it is absorbed, undergoing a metabolism during the "first passage" through the liver. When administered orally, its bioavailability is about 35%. Metabolites are excreted together with urine, less than 10% of the substance is excreted unchanged.
Indications:Infectious and inflammatory diseases of the mouth and throat: pharyngitis, laryngitis, catarrhal angina, stomatitis, ulcerative gingivitis, tonsillitis (as an auxiliary).
Contraindications:Hypersensitivity to individual components of the drug, sucrose / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, I trimester of pregnancy,period of breastfeeding, children's age (up to 6 years).
Carefully:Open wounds of the oral mucosa.
Pregnancy and lactation:It is not recommended to use in the first trimester of pregnancy, because the drug penetrates the placental barrier. The use of the drug in the II-III trimester of pregnancy is possible under the supervision of a doctor, in case the expected benefit for the mother exceeds the potential risk to the fetus. The drug is excreted in breast milk, so it is not recommended to use it during breastfeeding.
Dosing and Administration:

The tablet should be slowly resorbed in the mouth.

The tablet should not be chewed or swallowed. Do not take Teraflu®AP Menthol during or just before meals.

Adults and children over 12 years of age: 1 tablet every 1-2 hours for acute inflammation and severe pain. With a lighter condition, 1 tablet every 2-3 hours. The maximum daily dose is no more than 6 tablets.

Children from 6 to 12 years: 1 tablet every 3-4 hours as needed, the maximum daily dose - no more than 3 tablets.

Do not use TeraFlu® L tabletsAP Menthol more than 5 days in a row.If symptoms persist or are accompanied by fever, dizziness, or vomiting, stop taking the medication and consult a doctor.

Side effects:

Classification of incidence of adverse reactions:

very often - more than 1/10 appointments (> 10 %); often more than 1/100, but less than 1/10 of prescriptions

(> 1%, but < 10 %); infrequently - more than 1/1000, but less than 1/100 of prescriptions (> 0,1%, but < 1 %);

rarely - more than 1/10000, but less than 1/1000 appointments (> 0.01%, but < 0.1%); very rarely - less than 1/10000 prescriptions (< 0,01 %).

Disorders from the gastrointestinal tract:

Rarely: nausea;

Very rarely: diarrhea;

General disorders and disorders at the site of administration:

Rarely: local irritation of the mucous membrane of the mouth and throat.

Disturbances from the skin and subcutaneous tissues:

Very rarely: skin rash, itching.

Overdose:Accidental administration of high doses of the drug like other ammonium compounds can cause nausea and vomiting. In case of an overdose, it is recommended to take milk and whipped egg whites, and immediately stop taking the drug. The content of lidocaine hydrochloride in Teraflu® LAP Menthol is insignificant and can not cause serious overdose symptoms.
Interaction:Not found.
Special instructions:
The drug should not be taken immediately before meals and at the same time as milk. Simultaneous intake of the drug with milk and food can reduce local antiseptic and anesthetic effects. Alcohol increases the absorption of cetylpyridinium chloride, so you should avoid drinking alcohol when taking the drug.
The drug contains 1107 mg of sorbitol in 1 tablet as a sweetener, so it should not be taken by individuals with congenital intolerance to fructose. Cetylpyridinium chloride slows healing of wounds.

Effect on the ability to drive transp. cf. and fur:Does not affect.
Form release / dosage:
Tablets for resorption (menthol) 1 mg + 2 mg.


Packaging:
For 10 tablets in a blister of three-layer composite material PVC / PE / PVDC and aluminum foil. For 1 or 2 blisters together with instructions for use are placed in a cardboard box.
For 6 tablets in a blister of three-layer composite material PVC / PE / PVDC and aluminum foil. For 3 blisters together with instructions for use are placed in a cardboard box.
Storage conditions:At a temperature of no higher than 30 ° C. Keep out of the reach of children.
Shelf life:3 years.Do not use the drug after the expiration date.
Terms of leave from pharmacies:Without recipe
Registration number:LP-000981
Date of registration:18.10.2011
Date of cancellation:2016-10-18
The owner of the registration certificate:Новартис Консьюмер Хелс САНовартис Консьюмер Хелс СА Switzerland
Manufacturer: & nbsp
Representation: & nbspNOVARTIS CONSUMER HELS S.A. (part of Novartis groups) NOVARTIS CONSUMER HELS S.A. (part of Novartis groups) Switzerland
Information update date: & nbsp10.10.2015
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