Classification of the incidence of adverse events (WHO):
Often ; > 1/10 .
often . from> 1/100 to <1/10
infrequently from> 1/1000 to <1/100
rarely, from> 1/10000 to <1/1000
very rarely from <1/10000, including individual messages. ,
From the cardiovascular system:
- rarely: peripheral edema, orthostatic hypotension; very rarely: tachycardia, lowering blood pressure, changing the T wave on the ECG;
From the nervous system:
infrequently: headache, dizziness, drowsiness, restlessness; rarely: seizures or extrapyramidal disorders (torticollis, opisthotonus,
oculogic crisis (spasm of eyesight), rigidity of muscles, grimaces) - more often in children and adolescents; in elderly patients after prolonged use of the drug may develop tardive dyskinesia (involuntary movements);
very rarely: neuralgia of the trigeminal nerve, paradoxical reactions ("nightmarish" dreams, unusual agitation, nervousness, irritability);
From the sense organs:
rarely: clouding of the lens, miosis, decreased vision, hyperpigmentation of the retina; - On the part of the digestive system:
rarely: anorexia, dryness of the oral mucosa, constipation;
very often: cholestatic jaundice, paralytic intestinal obstruction, impaired liver function;
From the endocrine system:
rarely: gynecomastia, menstrual disorders, changes in libido, increase, body weight;
From the skin:
very rarely: exfoliative dermatitis, photosensitivity;
Allergic reactions:
very rarely: allergic reactions;
Laboratory indicators:
very rarely: thrombocytopenia, leukopenia, 'agranulocytosis,' 'aplastic' anemia // pancytopenia;
Other:
very rarely: impaired renal function.