Classification of the incidence of adverse events (WHO):
very often> 1/10
often from> 1/100 to <1/10
infrequently from> 1/1000 to <1/100
rarely from> 1 / 10,000 to <1/1000
very rarely from <1/10000, including individual messages.
From the cardiovascular system:
rarely: peripheral edema, orthostatic hypotension;
very rarely: tachycardia, lowering blood pressure, changing the T wave on the ECG;
From the nervous system.
infrequently: headache, dizziness, drowsiness, restlessness;
rarely: seizures or extrapyramidal disorders (torticollis, opisthotonus,
oculogic crisis (spasm of eyesight), rigidity of muscles, grimaces) - more often in children and adolescents; in elderly patients after prolonged use of the drug may develop tardive dyskinesia (involuntary movements);
very rarely: neuralgia of the trigeminal nerve, paradoxical reactions ("nightmarish" dreams, unusual agitation, nervousness, irritability);
From the sense organs:
rarely: clouding of the lens, miosis, decreased vision, retinal pigmentation;
From the digestive system:
rarely: anorexia, dryness of the oral mucosa, constipation;
very rarely: cholestatic jaundice, paralytic intestinal obstruction, impaired liver function;
From the endocrine system:
rarely: gynecomastia, menstrual irregularities, changes in libido, weight gain;
From the skin:
very rarely: exfoliative dermatitis, photosensitivity;
Allergic reactions:
very rarely: allergic reactions;
Laboratory indicators:
Very rarely: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia, pancytopenia;
Other:
very rarely: impaired renal function.