From the central nervous system: drowsiness, dizziness, insomnia (at the beginning of treatment), dry mouth, with prolonged use of high doses - akathisia, dystonic extrapyramidal disorders (spasms of the muscles of the face, neck and back, tick-like movements or twitches, bending movements of the trunk, inability to move eyes, weakness in hands and feet), parkinsonism (difficulty in speaking and swallowing, loss of balance control, masklike face shuffling Pgait, stiffness of hands and feet, trembling of hands and fingers), tardive dyskinesia (smacking lips, puffing cheeks, fast or vermiform dlanguage movements, uncontrolled chewing movements, uncontrolled movements of hands and feet). Dyskinesias are subcutaneously injected with 2 ml of 20% caffeine sodium solution and 1 ml 0.1% atropine solution),Neuroleptic malignant syndrome (convulsions, shortness or rapid breathing, palpitations or irregular heartbeats, hyperthermia, unstable arteriesexcessive pressure, sweating, utcontrol of urination, pronounced muscle regurgitation, unusually pale skin, unusual fatigue and weakness), phenomena of mental indeterminacy, belated reaction to external irritations and other changes in the psyche, in single cases - convulsions (as correctors use antiparkinsonian means - tropacin, cyclodol and other); paradoxical reactions - hallucinations, psychomotor agitation.
From the sense organs: blurred vision, paresis of accommodation (at the beginning of treatment), with prolonged use - retinopathy, clouding of the lens and cornea.
From the digestive system: loss of appetite, anorexia, constipation (at the beginning of treatment), bulimia, nausea, vomiting, diarrhea, gastralgia, rarely - cholestatic jaundice, hepatitis, intestinal paresis.
From the genitourinary system: retention of urine, decreased potency and libido, frigidity (at the beginning of treatment), ejaculation disorders, priapism, oliguria.
From the endocrine system: hypo- or hyperglycemia, glucosuria, amenorrhea, hyperprolactinemia, dysmenorrhea, galactorrhea, swelling or pain in the mammary glands, gynecomastia, weight gain.
Co cardiovascular system: tachycardia, frequent seizures stenocardia (against the background of increased physical activity), at the beginning of treatment - lowering blood pressure (including orthostatic hypotension) especially in elderly patients and people with alcoholism; heart rhythm disturbances, changes in the electrocardiogram (lengthening of the interval QT, decrease or inversion of the T wave).
Allergic reactions: cutaneous rash, hives, angioedema edema, exfoliative dermatitis.
Laboratory indicators: leukopenia, thrombocytopenia, anemia, agranulocytosis (on days 4-10), pancytopenia, eosinophilia (less often than other phenothiazines), hemolytic anemia, false positive tests for phenylketonuria, false positive pregnancy tests.
Other: photosensitization, skin and conjunctival staining, discoloration of sclera and cornea, decreased tolerance of high temperatures (up to the developmentheat stroke - hot dry skin, loss of sweating ability, muscle weakness, confusion), myasthenia gravis.
When taking neuroleptics phenotiazinovogo number of cases of sudden death (including possibly caused by cardiac causes).