Active substanceTrifluoperazineTrifluoperazine
Similar drugsTo uncover
  • Triftazine
    pills inwards 
  • Triftazine
    solution w / m 
  • Triftazine
    pills inwards 
    DALHIMFARM, OJSC     Russia
  • Triftazine
    solution w / m 
    DALHIMFARM, OJSC     Russia
  • Triftazin-Darnitsa
    solution w / m 
  • Dosage form: & nbspsolution for intramuscular injection
    Composition:

    In 1 ml of solution, contains:

    active substances: trifluoperazine hydrochloride 2 mg

    inactive substances: sodium citrate for injection, water for injection.

    Description:Transparent colorless or slightly colored liquid.
    Pharmacotherapeutic group:antipsychotic agent (antipsychotic)
    ATX: & nbsp

    N.05.A.B.06   Trifluoperazine

    Pharmacodynamics:Triftazine is a neuroleptic from the group of piperazine derivatives of phenothiazine. Has a pronounced antipsychotic and antiemetic effect, has alpha-adrenoceptor and weak anticholinergic and sedative effects. Neuroleptic effect is combined with a moderate stimulating effect (in small doses). Triftazin has a pronounced and prolonged effect on productive psychotic symptoms (hallucinations, delusions). Causes severe extrapyramidal disorders.
    Pharmacokinetics:

    Good is absorbed from the gastrointestinal tract and from places of parenteral administration. The time to reach the maximum concentration for intramuscular injection is 1-2 hours. The connection with plasma proteins is 95% (therefore, it is poorly dialyzed). Metabolised in the liver, half-life of 15-30 hours, most metabolites are pharmacologically inactive. It is excreted by the kidneys and with bile. Triftazine penetrates the placenta.

    Indications:

    - schizophrenia and other mental illnesses that occur with delirium, hallucinations and psychomotor agitation;

    - vomiting of the central genesis.

    Contraindications:

    - increased individual sensitivity;

    - oppression of the central nervous system and comatose states of any etiology;

    - brain trauma;

    - diseases of the liver, kidneys and hematopoietic organs with impaired functions;

    - progressive systemic diseases of the brain and spinal cord;

    - peptic ulcer of stomach and 12-intestinal gut during exacerbation;

    - heart failure in the stage of decompensation; severe arterial hypotension; diseases accompanied by a risk of thromboembolic complications;

    - Closed-angle glaucoma (risk of increased intraocular pressure);

    - hyperplasia of the prostate;

    - myxedema;

    - pregnancy, the period of breastfeeding;

    - children's age up to 3 years.

    Carefully:

    Elderly age, vomiting (antiemetic effect of phenothiazines may mask vomiting associated with overdose of other drugs).

    Triftazine is used after comparing the risk and benefit of treatment in patients with alcohol intoxication, Reye's syndrome, cachexia, as well as in breast cancer, Parkinson's disease, peptic ulcer and duodenal ulcer, urinary retention, chronic respiratory diseases (especially in children), epileptic seizures.

    Dosing and Administration:

    Intramuscularly, triftazine is used to achieve a rapid effect. The initial single dose is 1-2 mg (0.5-1 ml of solution) after 4-6 hours; with more frequent injections, cumulation phenomena are possible. The daily dose is 10 mg / day.

    Children from 6 years to 1 mg 1-2 times a day.

    In elderly patients, the initial dose should be halved, used with great care due to the special sensitivity of this group of patients, especially the extrapyramidal and hypotensive effects of the drug.

    As an anti-emetic, tryptazine is prescribed in doses of 1-4 mg per day.

    Treatment with trithazine should be strictly individualized depending on the course of the disease.

    Adults with vomiting - 1-2 mg 2 times a day. For elderly patients, the initial dose of the drug should be reduced by 2 times.

    Side effects:

    From the nervous system: drowsiness, dizziness, insomnia phenomena mental indifference, belated reaction to external stimuli. The use of triftazine is often accompanied by extrapyramidal racestriplets (dyskinesia, akinetorigidity phenomena, akathisia, hyperkinesia, tremor, autonomic disorders), in single cases convulsions. As proof-readers apply antiparkinsonian means - tropacin, trihexyphenidyl (cyclodol), etc. Dyskinesia (paroxysmally arising cramps in the muscles of the neck, tongue, mouth cavity, oculogic crises) are stopped by caffeine-sodium benzoate (2 ml of 20% solution subcutaneously) and atropine (1 ml 0.1% solution subcutaneously).

    With prolonged reception, it is possible to develop late dyskinesia, less often - malignant neuroleptic syndrome.

    From the sense organs: paresis of accommodation, with prolonged use - retinopathy, clouding of the lens and cornea.

    On the part of the genitourinary system: urinary retention, decreased potency, frigidity, decreased libido, ejaculatory disorders, priapism, oliguria.

    On the part of the endocrine system: hypo- or hyperglycemia, glucosuria, amenorrhea, hyperprolactinaemia, dysmenorrhea, galactorrhea, swelling or pain in the mammary glands, gynecomastia, weight gain.

    On the part of the digestive system: dry mouth, decreased appetite, constipation, bulimia, nausea, vomiting, diarrhea, gastralgia, cholestatic jaundice.

    From the sense organs: visual impairment - paresis of accommodation (at the beginning of treatment), retinopathy, clouding of the lens and cornea.

    Laboratory indicators: thrombocytopenia, lympho- and leukopenia, rise blood coagulability, anemia, agranulocytosis (usually at 4-10 weeks of treatment), pancytopenia, eosinophilia - less frequently than in other phenothiazines, false positive pregnancy tests.

    From the cardiovascular system: tachycardia, lowering blood pressure (including orthostatic hypotension), especially in elderly patients and people with alcoholism, heart rhythm disturbances, lengthening of the interval QT, decrease or inversion of the tooth T.

    Allergic reactions: skin rash, hives, angioedema (less often than other phenothiazines).

    Other: pigmentation of skin and conjunctiva, discoloration of sclera and cornea, a decrease in the tolerance of high temperatures (up to the development of heat stroke), melanosis

    Local reactions: with intramuscular injection, infiltrates may occur, when liquid forms enter the skin-contact dermatitis.

    Overdose:

    Symptoms: areflexia or hyperreflexia, blurred vision,

    cardiotoxic action (arrhythmia, heart failure, lowering of arterial pressure, shock, tachycardia, change in the complex QRS, ventricular fibrillation, cardiac arrest), neurotoxic effects, including agitation, confusion, convulsions, disorientation, drowsiness, stupor or coma; mydriasis, dry mouth, hyperpyrexia or hypothermia, muscle stiffness, vomiting, pulmonary edema, or respiratory depression.

    Treatment - symptomatic: with arrhythmia - in / in phenytoin 9-11 mg / kg, in heart failure - cardiac glycosides, with marked reduction of blood pressure - in / in a liquid or vasopressor agents such as norepinephrine, phenylephrine (avoid the appointment of alpha and beta-adrenomimetics, such as epinephrine, since a paradoxical decrease in arterial pressure is possible, due to the blockade of alpha-adrenoreceptors with trifluoperazine), with convulsions - diazepam (avoid the appointment of barbiturates, due to possible subsequent depression of the central nervous system and respiratory depression), with parkinsonism - diphenyltropine, diphenhydramine. Control of cardiovascular function for at least 5 days, functions of the central nervous system, respiration, measurement of body temperature, consultation of a psychiatrist. Dialysis is ineffective.

    Interaction:

    With the simultaneous use of triftazine with other drugs that exert a depressing effect on the central nervous system (drugs for general anesthesia, narcotic analgesics, ethanol (alcohol) and containing drugs, barbiturates, tranquilizers, etc.) may increase the depression of the central nervous system, as well as respiratory depression;

    undesirable long-term combination with analgesics and antipyretics - it is possible to develop hyperthermia;

    with tricyclic antidepressants, maprotiline or MAO inhibitors - an increased risk of neuroleptic malignant syndrome; fromanticonvulsants - it is possible to lower the convulsive threshold; with drugs for the treatment of hyperthyroidism - increases the risk of agranulocytosis; with other drugs that cause extrapyramidal reactions - it is possible to increase the incidence and severity of extrapyramidal disorders;

    with antihypertensive drugs - possible pronounced orthostatic hypotension; with ephedrine - it is possible to weaken the vasoconstrictive effect of ephedrine.

    In the treatment of triflazin, epinephrine (adrenaline) should be avoided, since the effect of epinephrine may be distorted, which can lead to a drop in blood pressure. The antiparkinsonian action of levodopa is reduced due to the blocking of dopamine receptors. Triftazine can inhibit the effects of amphetamines, clonidine, guanethidine.

    Triftazin increases the anticholinergic effects of other drugs, while the antipsychotic effect of neuroleptic may decrease.

    With the simultaneous use of Triftazine with prochlorperazine, a prolonged loss of consciousness may occur.

    The combination with lithium drugs increases the risk of extrapyramidal complications.

    Triftazin can mask some manifestations of ototoxicity (tinnitus, dizziness), drugs that have ototoxic effect (eg antibiotics).

    Other hepatotoxic drugs increase the risk of hepatotoxicity.

    Special instructions:

    During treatment it is necessary to carry out regular monitoring of blood pressure, pulse and liver, kidney and blood functions.

    During the treatment period, do not use alcohol!

    During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

    Form release / dosage:0,2% solution for intramuscular injection
    Packaging:

    0.2% solution in 1 ml ampoules, 5 ampoules per contour cell package, 2 contiguous cell packs in a pack of cardboard, together with instructions for use.

    Storage conditions:

    List B. In a place protected from light, inaccessible to children.

    Shelf life:

    3 years

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N002757 / 01-2003
    Date of registration:15.08.2008
    The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia
    Manufacturer: & nbsp
    Information update date: & nbsp18.10.2015
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