Troxevasin® Neo (Troxevasin® Neo)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHeparin sodium + Dexpanthenol + TroxerutinHeparin sodium + Dexpanthenol + Troxerutin
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  • Venolife®
    gel externally 
    AKRIKHIN HFK, JSC     Russia
  • Troxevasin® Neo
    gel externally 
    Actavis PTS ehf Group     Iceland
    • Dosage form: & nbspgel for external use
    Composition:In 1 g of gel contains:
    Active substances: troxerutin 20 mg, dexpanthenol 50 mg, sodium heparin 1.7 mg (corresponding to 300 IU);
    Excipients: carbomer 7 mg, propylene glycol 100 mg, methyl parahydroxybenzoate 0.8 mg, propyl parahydroxybenzoate 0.2 mg, trolamine 4.2 mg, water purified to 1 g.
    Description:Transparent or almost transparent gel from yellowish to greenish-yellow color.
    Pharmacotherapeutic group:anticoagulant direct action for topical application + other drugs
    ATX: & nbsp

    C.05.B.A.53   Heparin in combination with other drugs

    C.05.B.A   Heparin-containing preparations for topical application

    Pharmacodynamics:

    Troxevasin ® Neo - combined preparation for external use. The effect is due to the ingredients in its composition:
    Troxerutin - angioprotective agent.
    It has P-vitamin activity: it has venotonic, venoprotective, anti-edematous, anti-inflammatory, anticoagulant and antioxidant action.Reduces permeability and fragility of capillaries, increases their tone.
    Increases the density of the vascular wall. Promotes normalization of microcirculation and trophism of tissues, reduces stagnant phenomena.
    Heparin is an anticoagulant of direct action, a natural anticoagulant factor in the body. It prevents thrombosis, activates fibrinolytic properties of blood, improves local blood flow. Has anti-inflammatory effect, promotes regeneration of connective tissue due to inhibition of hyaluronidase activity.
    Dexpanthenol - provitamin B5 - in the skin it turns into pantothenic acid, which is a part of coenzyme A, which plays an important role in the processes of acetylation and oxidation. Improving metabolic processes, dexpanthenol contributes to the regeneration of damaged tissues; improves the absorption of heparin.

    Pharmacokinetics:With topical application, the active substances are quickly absorbed by the skin.
    Heparin accumulates in the upper layers and actively binds to the skin proteins. With external application, a small amount of heparin penetrates into the systemic blood stream, without having a systemic effect, without causing any changes in blood coagulation parameters.Does not penetrate the placental barrier.
    Dexpanthenol penetrates all layers of the skin and turns into pantothenic acid, binds to plasma proteins (mainly with beta-globulin and albumin). Pantothenic acid is not metabolized in the body and is excreted unchanged.
    Troxerutin after 30 minutes is found in the dermis, and after 2-5 hours in the subcutaneous fatty tissue. The penetration of troxerutin into the systemic blood flow is clinically insignificant.
    Indications:- Varicose veins;
    - Chronic venous insufficiency with such symptoms as: swelling and pain in the legs; feeling of heaviness, fatigue, tired legs; vascular asterisks and meshes, convulsions, paresthesia;
    - Thrombophlebitis;
    - Periphlebitis;
    - Varicose dermatitis;
    - Pain and edema of traumatic nature (with bruises, sprains, injuries).
    Contraindications:- open infected wounds or wounds with heavy exudation at the site of application;
    - hypersensitivity to the components of the drug
    - the age is under 18 years (no experience is available).
    Carefully:
    Pregnancy and lactation:Troxevasin® Neo is approved for use during pregnancy and lactation (breastfeeding).
    Dosing and Administration:Outwardly! The gel is applied a thin layer on the affected area 2 times a day in the morning and in the evening, evenly spreading on the surface of the skin with light rubbing movements until completely absorbed. If necessary, the gel can be applied under bandages or elastic stockings.
    The success of the drug treatment depends to a large extent on its regular application for a long time. The course of treatment is 2-3 weeks. The need for a longer treatment is determined by the attending physician.
    Repeated treatment is recommended 2-3 times a year.
    It is recommended to combine with the reception of capsules of Troxevasin ® to enhance the effect.
    Side effects:Allergic reactions: skin rash, itching (at the site of application of the drug).
    Overdose:Overdose is unlikely in connection with a small systemic absorption of the active components of the gel.
    Interaction:Interactions of the drug Troxevasin® Neo with other drugs have not been identified.
    Special instructions:Avoid getting on open wounds, mucous membranes and in the eyes!
    The drug Troxevasin® Neo is not intended for use in ophthalmology, for intravaginal and rectal administration.

    Effect on the ability to drive transp. cf.and fur:Against the background of taking the drug, there was no adverse effect on the ability to drive a car or other technical means.
    Form release / dosage:Gel for external use.
    Packaging:For 40 g of the drug in a membrane aluminum tube, 40 g or 100 g of the drug in a membrane laminate tube.
    Each tube together with the instruction for use is placed in a cardboard box.
    Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children!
    Shelf life:2 years. Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-002139
    Date of registration:12.07.2013 / 05.11.2014
    The owner of the registration certificate:Actavis PTS ehf GroupActavis PTS ehf Group Iceland
    Manufacturer: & nbsp
    Representation: & nbspAktavis, Open Company Aktavis, Open Company
    Information update date: & nbsp2016-01-13
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