Intravenous, intramuscular (only with complicated or uncomplicated urinary tract infections of mild or moderate severity caused by E.coli).
The dose and route of administration of the drug varies depending on the sensitivity of the microorganisms of the pathogens, the severity of the infection, and the state of kidney function in the patient.
Pneumonia (moderate to severe) caused by Streptococcus pneumoniae (including cases of association with concomitant bacteremia), Pseudomonas aeruginosa, Klebsiella pneumoniae or Enterobacter spp. - intravenously 1.0 -2.0 g every 12 hours for 10 days.
Febrile neutropenia (empirical therapy) - intravenously 2.0 g every 8 hours for 7 days or until neutropenia is resolved.
Complicated or uncomplicated urinary tract infections mild and severe due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis - intravenously or intramuscularly (for infections caused by Escherichia coli) - at 0.5-1.0 g every 12 h for 7- 10 days.
Severe complicated or uncomplicated urinary tract infections (including pyelonephritis) caused by Escherichia coli or Klebsiella pneumoniae -vnutrivenno 2.0 g every 12 hours for 10 days.
Moderate and severe skin and soft tissue infections caused by Staphylococcus aureus (only metitsillinchuvstvitelnye strains), Streptococcus pyogenes - 2.0 g intravenously every 12 hours for 10 days.
Complicated intra-abdominal infections (in combination with metronidazole) caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp. - intravenously 2.0 g every 12 hours for 7-10 days.
For the prevention of infection during surgery on abdominal organs: for 60 min before surgery introduced 2.0 g of the drug intravenously over 30 min. At the end of the infusion, add an additional 500 mg of metronidazole intravenously. Metronidazole solutions should not be administered concomitantly with cefepime. Infusion system before the introduction of metronidazole should be washed.During prolonged (more than 12 hours) surgical operations 12 hours after the first dose, repeated administration of 2.0 g of the drug intravenously for 30 minutes is recommended, followed by the administration of 500 mg of metronidazole.
Children from 2 months to 16 years and weighing up to 40 kg for all indications (excluding febrile neutropenia) - intravenously 50 mg / kg every 12 hours; with febrile neutropenia - 50 mg / kg every 8 hours. Duration of treatment as in adults. The maximum dose should not exceed the recommended dose for adults.
In chronic renal failure, the dose is prescribed depending on the severity of the infection and the clearance of creatinine.
| Creatinine clearance (ml / min) | Dosing regimen |
| More than 60 | 0.5 -1 - 2 g every 12 h |
| | or 2 g every 8 hours |
| 30-60 | 0.5-1-2 g every 24 hours |
| | or 2 g every 12 h |
| 11-29 | 0.5 - 0.5 -1 g every 24 hours |
| | or 1 g every 12 hours |
| Less than 11 | 0.25-0.25-0.5 g every 24h |
| | or 1 g every 24 hours |
| Permanent outpatient | 0.5 - 1 - 2 g every 48 hours |
| peritoneal dialysis | |
Patients on hemodialysis on day 1 are given 1.0 g, then 0.5 g every 24 hours for all infections and 1.0 g every 24 hours for the treatment of febrile neutropenia.
On the day of hemodialysis, the drug is administered after the end of the hemodialysis session; it is desirable to enter cefepime every day at the same time.
Data on the use of the drug in children with concomitant chronic renal insufficiency are not available, however, given the similar pharmacokinetics in children and adults, the dosage regimen (decrease or increase in the interval between administrations) in children with chronic renal insufficiency resembles the dosing regimen in adults.
Preparation of the solution:
For intravenous administration, the preparation (1.0 g) is dissolved in 10 ml of a solvent. Sterile water for injection, 5% dextrose solution or 0.9% sodium chloride solution are used as the solvent. Intravenously injected for 3-5 minutes.
For intravenous infusions, the prepared solution is combined with other solutions for intravenous infusions (5% or 10% dextrose solution, 0.9% sodium chloride solution, Ringer's solution with lactate and 5% dextrose solution, maximum concentration 40 mg / ml). The duration of infusion is not less than 30 min.
For intramuscular injection, the preparation (1.0 g) is dissolved in 2.4 ml of sterile water for injection, 0.9% solution of sodium chloride, bacteriostatic water for injection with paraben or benzyl alcohol, in 0.5% or 1% lidocaine solution.