Cyanocobalamin-Vial (Cyanocobalamin-Vial)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substanceCyanocobalaminCyanocobalamin
Similar drugsTo uncover
  • Cyanocobalamin
    solution for injections 
    ATOLL, LLC     Russia
  • Cyanocobalamin
    solution for injections 
    MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC     Russia
  • Cyanocobalamin
    solution for injections 
    StatusPharm, LLC     Russia
  • Cyanocobalamin
    solution for injections 
    DALHIMFARM, OJSC     Russia
  • Cyanocobalamin
    solution for injections 
    NOVOSIBHIMFARM, OJSC     Russia
  • Cyanocobalamin
    solution for injections 
    BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC     Republic of Belarus
  • Cyanocobalamin
    solution for injections 
    LVIVODIALEK DP KAK UKRMEDPROM     Ukraine
  • Cyanocobalamin (Vitamin B12)
    solution for injections 
    VEROPHARM SA     Russia
  • Cyanocobalamin bufus
    solution
    UPDATE OF PFC, CJSC     Russia
  • Cyanocobalamin bufus
    solution for injections 
    UPDATE OF PFC, CJSC     Russia
  • Cyanocobalamin-Vial
    solution
    VIAL, LLC     Russia
  • Cicomin-Altpharm
    suppositories rect. 
    ALTFARM, LLC     Russia
    • Dosage form: & nbsp
    Injection.

    Composition:
    1 ml of the solution contains:

    active substance: cyanocobalamin 0.2 mg and 0.5 mg;

    Excipients: sodium chloride, hydrochloric acid 0.1 M, water for injection.
    Description:

    For a dosage of 0.2 mg / ml: transparent liquid from slightly pink to pink.

    For a dosage of 0.5 mg / ml: transparent liquid from bright pink to bright red.

    Pharmacotherapeutic group:Vitamin.
    ATX: & nbsp

    B.03.B.A.01   Cyanocobalamin

    Pharmacodynamics:
    Cyanocobalamin has a metabolic, hematopoietic effect. In the body (mainly in the liver) is converted into a coenzyme form - adenosylcobalamin or kobamid, which is an active form of vitamin B12 and is a part of numerous enzymes, including. in the reductase that restores folic acid to tetrahydrofolic. Has a high biological activity. Cobamamide participates in the transfer of methyl and other single carbonaceous fragments, so it is necessary for the formation of deocheiribose and DNA, creatine, methionine-donor of methyl groups, in the synthesis of lipotropic factor-choline, for the conversion of methylmalonic acid to amber, which is part of myelin, for the utilization of propionic acid . It is necessary for normal hematopoiesis - promotes the maturation of red blood cells.
    Promotes the accumulation in erythrocytes of compounds containing sulfhydryl groups, which increases their tolerance to hemolysis. Activates the blood coagulation system, in high doses causes an increase in thromboplasty activity and prothrombin activity.Reduces cholesterol in the blood. Has a beneficial effect on the function of the liver and nervous system. Increases the ability of tissues to regenerate.
    Pharmacokinetics:
    In blood cyanocobalamin binds to the trans-balanamines I and II, which transport it into tissues. It is deposited mainly in the liver. The connection with plasma proteins is 90%. The maximum concentration after subcutaneous and intramuscular injection is achieved after 1 hour.
    From the liver is excreted with bile into the intestine and again absorbed into the blood. Half-life is 500 days. It is excreted at normal kidney function - 7-10% by kidneys, about 50% - with calves; with a decrease in kidney function - 0-7% by kidney, 70-100% - with mucus masses. Penetrates through the placental barrier, into breast milk.
    Indications:

    Conditions accompanied by vitamin B12 deficiency:

    Chronic anemia, occurring with a deficiency of vitamin B12 (Addison-Birmer disease, alimentary macrocytic anemia), as part of complex therapy of anemia (including iron deficiency, posthemorrhagic, aplastic, anemia caused by toxic substances and / or drugs).

    In complex therapy:

    Chronic hepatitis, cirrhosis, hepatic insufficiency, alcoholism.

    In Neurology: polyneuritis, radiculitis, hypotrophy, neuralgia (including trigeminal neuralgia), peripheral nervous system diseases of traumatic origin, cerebral palsy, Down's disease.

    In dermatology: psoriasis, photodermatosis, herpetiform dermatitis, atopic dermatitis.

    With the preventive purpose: in the appointment of biguanides, PASK, ascorbic acid in high doses, abnormalities of the stomach and intestines with a violation of the absorption of cyanocobalamin (resection of part of the stomach, small intestine, Crohn's disease, malabsorption syndrome, sprue), enteritis, diarrhea, radiation sickness.

    Contraindications:Hypersensitivity to the drug components, thromboembolism, erythremia, erythrocytosis, pregnancy (there are separate indications of possible teratogenic effects of B vitamins in high doses), lactation period.
    Carefully:Angina pectoris, benign and malignant neoplasms, accompanied by megaloblastic anemia and cyanocobalamin deficiency, propensity to form blood clots
    Dosing and Administration:
    The drug is administered subcutaneously, intramuscularly, intravenously.

    Subcutaneously, with Addison-Birmer anemia, 100-200 μg / day every other day; with funicular myelosis, macrocytic anemia with violation of the nervous system function - 400-500 mcg / day in the first week - daily, then with intervals between administrations up to 5-7 days (concomitantly prescribe folic acid); during the remission, the maintenance dose is 100 mcg / day 2 times a month, in the presence of neurologic symptoms - 200-400 mcg 2-4 times a month.

    In acute posthemorrhagic and iron deficiency anemia - 30-100 mcg 2-3 times a week; with aplastic anemia - 100 mcg before the onset of clinical and hematologic improvement. With violations of the nervous system - 200-400 mcg 2-4 times a month.

    In diseases of the central nervous system and peripheral nervous system - 200-500 mcg every other day for 2 weeks. In diseases of the peripheral nervous system of traumatic genesis - 200-400 mcg every other day for 40-45 days. With hepatitis and cirrhosis of the liver - 30-60 mcg / day or 100 mcg every other day for 25-40 days.

    With radiation sickness - 60-100 mcg daily for 20-30 days.

    To eliminate the deficiency of vitamin B12 is administered intramuscularly (in / m) or intravenously (iv) 1 mg daily for 1-2 weeks.

    Young children with alimentary anemia and premature babies are subcutaneously 30 μg per day every day for 15 days. In dystrophies in young children, Down's disease and cerebral palsy - subcutaneously 15-30 mcg every other day.
    Side effects:Allergic reactions, mental agitation, cardialgia, tachycardia, diarrhea, headache, dizziness. When used in high doses - hypercoagulation, violation of purine metabolism.
    Interaction:
    Pharmaceutically incompatible with ascorbic acid, heavy metal salts (inactivation of cyanocobalamin), thiamine bromide, pyridoxine, riboflavin (because the cobalt ion contained in the cyanoballamine molecule destroys other vitamins).
    You can not combine with drugs that increase blood coagulability.
    Aminoglycosides, salicylates, antiepileptic drugs, colchicine, potassium preparations reduce the absorption of cyanocobalamin.
    The risk of developing allergic reactions increases when combined with thiamine.
    Increases the toxic effect in combination with folic acid. Chloramphenicol reduces the hematopoietic response of cyanocobalamin.
    Special instructions:Deficiency of vitamin B12 should be confirmed diagnostically prior to prescribing, as it can mask a deficiency of folic acid. During the period of treatment, it is necessary to monitor the parameters of peripheral blood: on the 5th-8th day of treatment, the content of reticulocytes, the concentration of iron is determined. The number of erythrocytes, hemoglobin and color index should be monitored within 1 month. 1-2 times a week, and then - 2-4 times a month. Remission is achieved with an increase in the number of red blood cells to 4-4.5 million / μl, when normal erythrocyte sizes reach, aniso-and poikilocytosis disappear, normalizing the content of reticulocytes after a reticulocytic crisis. After reaching hematological remission, control of peripheral blood is carried out at least once in 4-6 months. Be careful in individuals prone to thrombosis, with angina (in smaller doses up to 0.1 mg per injection). Take a long time with pernicious anemia, the upcoming operations on the gastrointestinal tract.
    Form release / dosage:Solution for injection 0.2 mg / ml and 0.5 mg / ml.
    Packaging:1 ml per ampoule of neutral colorless glass. 10 ampoules per contour cell package.One contour pack with instructions for use in a cardboard box.
    Storage conditions:List B. Store in a dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:3 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001942/09
    Date of registration:16.03.2009
    The owner of the registration certificate:VIAL, LLC VIAL, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp01.12.2015
    Illustrated instructions
      Instructions
      Up