Active substanceCyanocobalaminCyanocobalamin Similar drugsTo uncover Cyanocobalamin solution for injections ATOLL, LLC Russia Cyanocobalamin solution for injections MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia Cyanocobalamin solution for injections StatusPharm, LLC Russia Cyanocobalamin solution for injections DALHIMFARM, OJSC Russia Cyanocobalamin solution for injections NOVOSIBHIMFARM, OJSC Russia Cyanocobalamin solution for injections BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus Cyanocobalamin solution for injections LVIVODIALEK DP KAK UKRMEDPROM Ukraine Cyanocobalamin (Vitamin B12) solution for injections VEROPHARM SA Russia Cyanocobalamin bufus solution UPDATE OF PFC, CJSC Russia Cyanocobalamin bufus solution for injections UPDATE OF PFC, CJSC Russia Cyanocobalamin-Vial solution VIAL, LLC Russia Cicomin-Altpharm suppositories rect. ALTFARM, LLC Russia Dosage form: & nbspSuppositories rectal. Composition:Active substance: Cyanocobalamin 0.5 mg Excipients: glycerol (glycerol) 25 mg, lanolin anhydrous 25 mg, fatty acid glycerides (whitespine H 15) 1049.5 mg Description:Suppositories of pink color torpedo-shaped. Pharmacotherapeutic group:Vitamin. ATX: & nbspB.03.B.A.01 Cyanocobalamin Pharmacodynamics:Cyanocobalamin (vitamin B12) has a metabolic, hematopoietic effect. Participates in the synthesis of labile methyl groups and in the formation of choline, methionine, creatine, nucleic acids; promotes the accumulation in erythrocytes of compounds containing sulfhydryl groups. In high doses causes an increase in thromboplasty activity and prothrombin activity. Activates the metabolism of carbohydrates and lipids. Indications:Treatment and prevention of vitamin B12 deficiency.Complex therapy of polyneuritis, radiculitis, neuralgia (including trigeminal neuralgia), hypotrophy, funicular myelosis, peripheral nerve injury, amyotrophic lateral sclerosis. Contraindications:Increased individual sensitivity to the components of the drug, thromboembolism, erythremia, erythrocytosis, pregnancy, lactation. Carefully:the drug is prescribed for patients with angina pectoris; benign and malignant neoplasms, accompanied by megaloblastic anemia and vitamin B12 deficiency, with a tendency to form blood clots. Pregnancy and lactation:The drug is not recommended during pregnancy and breastfeeding. Dosing and Administration:Adults to eliminate vitamin B12 deficiency - 1 mg (2 suppositories) daily for 1-2 weeks, for the prevention of vitamin B12 deficiency - 1 mg (2 suppositories) once a month. In diseases of the peripheral nervous system - 500 mcg (1 suppository) every other day for 2 weeks. Side effects:Allergic reactions to the components of the drug, cardialgia, tachycardia, diarrhea, headache, dizziness, mental agitation. When used in high doses - hypercoagulation, violation of purine metabolism. Interaction:You can not combine with drugs that increase blood coagulability.Chloramphenicol reduces the hemopoietic response when used concomitantly with cyanocobalamin. Thiamine increases the risk of allergic reactions. Special instructions:Deficiency of vitamin B12 should be confirmed. During the treatment it is necessary to monitor the blood counts: on the 5th-8th day of treatment, the content of reticulocytes, the concentration of iron, is determined. The number of red blood cells, Hb and color index should be monitored for 1 month 1-2 times a week, and then 2-4 times a month. Remission is achieved with an increase in the number of red blood cells to 4-4.5 million / μl,when normal sizes of erythrocytes are reached, the aniso- and poikilocytosis disappear, the reticulocyte content is normalized after the reticulocytic crisis. After reaching hematologic remission, peripheral blood monitoring is performed at least once every 4-6 months. Form release / dosage:Suppositories rectal 0,5 mg. Packaging:There are 5 suppositories in a contiguous cell package. 2 contour mesh packages together with instructions for use in a pack of cardboard. Storage conditions:Store in a dark place at a temperature of no higher than 15 ° C.Keep out of the reach of children. Shelf life:2 years. Do not use after the expiry date printed on the package. Terms of leave from pharmacies:On prescription Registration number:LSR-006594/08 Date of registration:14.08.2008 The owner of the registration certificate:ALTFARM, LLC ALTFARM, LLC Russia Manufacturer: & nbspALTFARM, LLC Russia Information update date: & nbsp01.12.2015 Illustrated instructions × Illustrated instructions Instructions