The incidence of side effects is given in the following gradation: very often (> 1/10); often (> 1/100, <1/10); infrequently (> 1/1000, <1/100); rarely (> 1/10000, <1/1000); very rarely (<1/10000), including individual messages.
From the nervous system: not often - drowsiness, myoclonia, mental disorders, hallucinations, confusion, epileptic seizures; rarely - hearing loss; very rarely - headache, ringing in the ears; encephalopathy, paresthesia, asthenia.
From the sense organs: rarely - hearing loss, ringing in the ears, perversion of taste.
From the urinary system: rarely - oliguria, anuria, polyuria, proteinuria, the appearance of protein, erythrocytes, leukocytes, urinary cylinders, increased bilirubin concentration and a change in urine color (safe and should not be mistaken for hematuria), kidney failure. The effect of the drug in changes in renal function is difficult to assess, since there are usually other factors,predisposing to prerenal azotemia or impaired renal function.
From the gastrointestinal tract: often - nausea, vomiting, diarrhea; rarely - hypertrophy of the papillae of the tongue, pain in the pharynx, abdominal pain, glossitis, hypersalivation, dental pigmentation and / or language, pseudomembranous enterocolitis (clinically significant as in the case of other broad-spectrum antibacterial drugs) (see "With caution" ), both during and after the completion of treatment, hepatitis; very rarely - gastroenteritis, fulminant hepatitis, hepatic insufficiency, jaundice.
From the respiratory system: very rarely - a feeling of discomfort in the chest, shortness of breath, hyperventilation, pain in the thoracic spine, burning behind the sternum.
From the side of the cardiovascular system: not often - lowering blood pressure; rarely: palpitation, tachycardia.
Laboratory indicators:
- biochemical: often - increased activity of "liver" transaminases and alkaline phosphatase; infrequently - hyperbilirubinemia, hypercreatininaemia, increased concentration of urea nitrogen; direct positive Coombs test;
- hematological: infrequently - pancytopenia, thrombocytopenia, thrombocytosis, leukopenia, neutropenia, leukocytosis, monocytosis, lymphocytosis, an increase in the number of basophils, a decrease in hemoglobin and hematocrit, an increase in prothrombin time; often - eosinophilia, rarely - agranulocytosis; very rarely - oppression of the red bone marrow function, hemolytic anemia.
Against the background of granulocytopenia, more frequent episodes of nausea and vomiting are noted. Electrolyte balance: infrequent - decrease in serum sodium and chloride concentration, increase in potassium concentration.
Allergic reactions: often - skin rash, itching; infrequently - hives; rarely - multiforme exudative erythema (including Stevens-Johnson syndrome), angioedema, toxic epidermal necrolysis, exfoliative dermatitis, fever; very rarely - anaphylactic reactions, cyanosis, hyperhidrosis.
Local reactions: often - skin hyperemia, thrombophlebitis; infrequently - pain at the injection site; erythema at the injection site, infection at the injection site.
Other: very rarely - candidiasis, itching of the vagina, a taste disorder, polyarthralgia.