Clinically important adverse reactions:
Acute renal failure, impaired liver function.
If any of the following adverse reactions are found, appropriate measures should be taken, such as a reduction in dosage or a break in taking the drug.
From the gastrointestinal tract:
Nausea, bloating, dyspepsia, constipation, decreased appetite, heartburn, epigastric discomfort, gastralgia, metallic taste in the mouth, dry mouth, slight increase in the activity of "liver" transaminases.
From the nervous system:
Headaches, insomnia, irritability, weakness, dizziness, drowsiness, memory problems, tinnitus, hearing loss, back pain, stiff shoulder stiffness, lower extremity cramps, chest pains, fatigue, dysphoria.
From the cardiovascular system:
Increased blood pressure (BP), tachycardia, arrhythmogenic effect.
From the musculoskeletal system:
Periarticular calcification (excessive bone formation), moderate pain in the bones, arthralgia.
From the side of metabolism:
Hypercalcemia, an increase in high-density lipoproteins, hyperphosphataemia (patients with severe renal dysfunction).
From ophthalmology:
Hyperemia of the conjunctiva.
Other: weight loss, polydipsia, nocturia, photophobia, hoarseness, kidney stones may be formed, allergic reactions (skin rash, itching, sensation of heat) are possible.