Vasoket® (Vasocet®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDiosminDiosmin
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    • Dosage form: & nbsppills
    Composition:

    Active substance: diosmin 600 mg

    Excipients: povidone, microcrystalline cellulose, corn starch, magnesium stearate.

    Description:

    Oblong tablets from grayish-yellow to light-yellow color with a fault line on both sides.

    Pharmacotherapeutic group:Venotonizing and venoprotective agent
    ATX: & nbsp

    C.05.C.A.03   Diosmin

    Pharmacodynamics:Diosmin has a venotonic effect (reduces vein dilatation, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of lymphatic capillary contraction, increases their functional density, decreases lymphatic pressure), improves microcirculation (increases resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into parainous tissues, improves diffusion of oxygen and erfuziyu in dermal tissue, it possesses anti-inflammatory action.Strengthens the vasoconstrictive effect of adrenaline, norepinephrine, serotonin, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
    Pharmacokinetics:After ingestion, the drug is rapidly absorbed from the gastrointestinal tract and is determined in the blood plasma after 2 hours. The maximum concentration in the blood plasma is reached after 5 hours after administration. Evenly distributed and accumulated in all layers of the wall are hollow veins and subcutaneous veins of the lower limbs, to a lesser extent - in the kidneys, liver, lungs and other organs. The selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after administration and lasts for 96 hours. Displayed diosmin kidneys 79%, intestines - 11%, with bile - 2.4%.
    Indications:Varicose veins of the lower extremities, chronic lymphovenous insufficiency of the lower limbs; exacerbation of hemorrhoids; disturbance of microcirculation.
    Contraindications:

    Hypersensitivity to the components of the drug, children's age (under 18 years).

    Pregnancy and lactation:

    So far, in clinical practice, there have been no reports of any side effects in the use of the drug inpregnant women. In experimental studies, there was no teratogenic effect on the fetus. During breastfeeding, taking the medication is not recommended, since there is no data on the penetration of the drug into breast milk.

    Dosing and Administration:

    With varicose veins of the lower extremities and in the initial stage of chronic lymphovenous insufficiency (heaviness in the legs), 1 tablet per day is prescribed in the morning before breakfast for 2 months, with severe forms of chronic lymphovenous insufficiency (swelling, pain, cramps, etc.) - treatment is continued for 3-4 months, with trophic changes and ulcers prolonged treatment for up to 6 months or more. The course is repeated after 2-3 months.

    With an exacerbation of hemorrhoids prescribe a drug of 2-3 tablets a day during meals for 7 days, then, if necessary, you can continue 1 tablet 1 time per day for 1-2 months.

    In the treatment of chronic lymphovenous insufficiency during the II and III trimester of pregnancy, 1 tablet is prescribed 1 time per day and is canceled 2-3 weeks before the birth.

    If you missed one or more of the techniques, continue using the drug in the usual dosage.

    Side effects:In rare cases from the gastrointestinal tract - dyspeptic disorders, from the central nervous system - headache.
    Overdose:

    Symptoms of overdose are not described.

    Interaction:

    Clinically significant effects of interaction with other drugs are not described.

    Special instructions:

    acute hemorrhoid treatment is carried out in combination with other drugs, in the absence of rapid clinical effect it is necessary to conduct an additional inspection and adjust the therapy.

    There is evidence of the possible efficacy in the treatment of placental insufficiency, for the prevention of bleeding caused by use of intrauterine devices and between phlebectomy.

    Form release / dosage:Tablets of 600 mg.
    Packaging:

    For 15 tablets in a blister of polyvinylchloride film and aluminum foil.

    For 1 or 2 blisters together with instructions for use in a pack of cardboard.

    Storage conditions:

    At a temperature of no higher than 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001940
    Date of registration:01.04.2011 / 10.07.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:Stragen Farma S.A.Stragen Farma S.A. Switzerland
    Manufacturer: & nbsp
    Representation: & nbspYUSB FARMA LLC YUSB FARMA LLC Russia
    Information update date: & nbsp10.01.2017
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