Intravenously.
The recommended concentration is no more than 5 mg / ml with a rate of administration of not more than 10 mg / min; the duration of the infusion should be at least 60 minutes.
Adults: 500 mg or 7.5 mg / kg every 6 hours or 1000 mg or 15 mg / kg every 12 hours.
For children: Newborn children during the first week of life - an initial dose of 15 mg / kg, followed by 10 mg / kg every 12 hours; beginning with the second week of life, apply the same dose every 8 hours; for children older than 1 month - 10 mg / kg every 6 hours or 20 mg / kg every 12 hours.
Patients with impaired renal excretory function correction of the dosing regimen is required taking into account the values of creatinine clearance (CK). Correction can be carried out by increasing the intervals between injections of Vero-Vancomycin, or by reducing the single dose of the drug.
Correction by increasing the intervals between the administrations:
At CC more than 80 ml / min - the usual dosing regimen, with KK 50-80 ml / min - 1000 mg every 1-3 days, with KK 10-50 ml / min - 1000 mg every 3-7 days, with QC less than 10 ml / min - 1000 mg every 7-14 days.
Correction of a single dose:
| Creatinine clearance (ml / min) | Vancomycin Dose (mg / 24 hours) |
| 100 | 1545 |
| 90 | 1390 |
| 80 | 1235 |
| 70 | 1080 |
| 60 | 925 |
| 50 | 770 |
| 40 | 620 |
| 30 | 465 |
| 20 | 310 |
| 10 | 155 |
Patients with anuria Vero-vancomycin should be given at an initial dose of 15 mg / kg to quickly create a therapeutic concentration of the drug in the blood serum. The dose required to maintain a stable concentration is 1.9 mg / kg per day. Patients with severe renal dysfunction should be given maintenance doses of 250-1000 mg once every few days than on a daily schedule. When anuria is recommended to administer 1000 mg every 7-14 days.
When only the concentration of serum creatinine is known, the following formula can be used to calculate the creatinine clearance: for men - [body weight (kg) x (140 - age (years)] / [72 x serum creatinine concentration (mg / dl) )], for women - the result is multiplied by 0.85.
Preparation of the solution: The lyophilizate is dissolved in water for injection: 500 mg in 10 ml, 1 g in 20 ml (the concentration of the solution is 50 mg / ml). The resulting solution is subject to further dilution with 0.9% sodium chloride solution or 5% dextrose solution to a concentration of not more than 5 mg / ml (for 500 mg - 100 ml and for 1 g - 200 ml). Solutions prepared on the basis of 0.9% sodium chloride or 5% dextrose can be stored in a refrigerator (2-8 ° C) for 14 days without significant loss of activity.
Application inside with pseudomembranous colitis, staphylococcal enterocolitis: daily dose for of adults - 500-2000 mg, divided into 3-4 doses; for children - 40 mg / kg, divided into 3-4 admission. The maximum daily dose for adults and children is 2000 mg. Duration of treatment is 7-10 days.
The solution for oral ingestion is prepared by dissolving the appropriate dose of lyophilizate in 30 ml of water.