In the treatment of lacosamides, the most frequent adverse reactions were dizziness (also the main cause of lacosamid abolition), headache, nausea and diplopia. As a rule, they were mild or moderate. The severity of some adverse reactions depended on the dose and decreased after its reduction. The frequency and severity of adverse reactions from the central nervous system (CNS) and gastrointestinal tract usually decreased with time. The use of lacosamide is accompanied by a dose-dependent lengthening of the interval PR, so that the development of clinical conditions such as atrioventricular blockade, fainting and bradycardia is possible.
Adverse reactions noted in more than 1% of patients in clinical trials are listed below. Adverse reactions are classified by frequency according to the following categories:
Often (>1/10);
Often (more than 1/100 and less than 1/10);
Infrequently (more ≥1/1000 and less than <1/100).
From the central nervous system and psyche
Very often: dizziness, headache.
Often: depression, irritability, imbalance, impaired coordination of movements, memory impairment, attention impairment, cognitive impairment, hypoesthesia, drowsiness, confusion, tremor, nystagmus, dysarthria.
From the side of the cardiovascular system
Bradycardia (frequency not established).
From the side of the organ of vision
Very often: diplopia.
Often: blurred vision.
From the side of the hearing and vestibular organs
Often: vertigo, noise in the ears.
From the gastrointestinal tract
Very often: nausea.
Often: vomiting, constipation, flatulence, indigestion, dry mouth.
From the skin and subcutaneous fat
Often: itching.
Rash (frequency not established).
From the musculoskeletal system
Often: muscle spasms.
Other
Often: gait disturbance, asthenia, fatigue, falls, increased risk of injury (due to impaired coordination of movements and dizziness).