Vinpocetine - instructions for use, dose, side effects, contraindications

Composition:active ingredient - vinpocetine (in terms of 100% substance) 5 mg / ml excipients - ascorbic acid, sodium metabisulphite, gasoline alcohol, tartaric acid, sodium tartrate, sorbitol (D-sorbitol), water for injection.

Description:transparent colorless or slightly colored liquid.

Pharmacotherapeutic group:cerebral blood flow improver

ATX: & nbsp

N.06.B.X.18 Vinpocetine

Pharmacodynamics:Has vasodilator, antihypoxic and antiaggregatory action. It inhibits phosphodiesterase and increases the content of cyclic adenosine monophosphate in cells, which in turn leads to a decrease in calcium content in the cytoplasm of smooth muscle cells and relaxation of myofibrils.It combines vascular and metabolic actions. It dilates the blood vessels of the brain, increases blood flow, mainly in ischemic areas, improves the supply of oxygen to the brain. Promotes the utilization of glucose and increases the level of catecholamines in the central nervous system, stimulates the metabolism of norepinephrine and serotonin in the brain tissues. Reduces platelet aggregation, blood viscosity, promotes increased erythrocyte deformability and improved venous outflow against a background of decreased resistance of cerebral vessels. Systemic blood pressure slightly decreases. In acute stage of stroke accelerates the regress of cerebral and focal neurological symptoms, improves memory, attention, intellectual productivity. In the elderly and senile age, the sensitivity of the cerebral vessels to the relaxing action of vinpocetin increases, which is due to the sensitization of the adenylate cyclase system - cyclic adenosine monophosphate upon aging.

Pharmacokinetics:

With parenteral administration, it easily penetrates through the histohematological barriers (including through the blood-brain barrier). The volume of distribution is 5.3 l / kg body weight.The half-life is about 4.74 hours.

Indications:

- acute and chronic forms of cerebral circulatory insufficiency (transient ischemic attacks, acute and residual stages of stroke, encephalopathy);

- mental and neurological disorders associated with cerebrovascular insufficiency (memory disorders, dizziness, headache, aphasia, apraxia, motor disorders).

- in ophthalmology: in vascular diseases of the retina and / or choroid of the eye; with degenerative changes of the yellow spot caused by atherosclerosis or angiospasm; with partial occlusion of vessels, secondary glaucoma.

- in otolaryngology with senile hearing loss, Meniere's disease, deterioration of hearing of vascular or toxic (including medicamentous) genesis, with dizziness of labyrinth origin.

Contraindications:

Hypersensitivity; severe ischemic heart disease; severe forms of heart rhythm disturbances; acute phase of hemorrhagic stroke; pregnancy and lactation.

Dosing and Administration:

Intravenously drip. 20 mg is diluted in 250-400 ml of the infusion solution. With good tolerability, the dose of the drug within 3-4 days is increasedwup to 1 mg / kg, treatment is continued for 10-14 days. After completing the course of parenteral administration, they switch to oral administration of the drug. Before drug cancellation the dose should be gradually reduced.

Side effects:

Dizziness, a feeling of heat, hyperemia of the facial skin, nausea, thrombophlebitis at the injection site. From the side of the cardiovascular system, transient decrease in arterial pressure, tachycardia, extrasystole, an increase in the time of excitation of the ventricles, thrombophlebitis at the site of administration can be observed.

Overdose:

Increases the risk of hemorrhagic complications against heparin therapy. The solution of Vinpocetine is pharmaceutically incompatible with heparin.

Interaction:

Concentrate for the preparation of solution for infusions 5 mg / ml. 2 ml into the ampoules of the light-protective glass. 5 ampoules per contour cell packaging made of polyvinyl chloride film. 2 contour packs with instructions for use and a knife for opening ampoules or a scarifier in a pack of cardboard (when packing ampoules with a ring or break point, the ampoule opener or scarifier does not invest).

Form release / dosage:Concentrate for the preparation of solution for infusions 5 mg / ml.

Packaging:

2 ml into the ampoules of the light-protective glass. 5 ampoules per contour cell packaging made of polyvinyl chloride film. 2 contour packs with instructions for use and a knife for opening ampoules or a scarifier in a pack of cardboard (when packing ampoules with a ring or break point, the ampoule opener or scarifier does not invest).

Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-006068/08

Date of registration:31.07.2008

The owner of the registration certificate:Company DEKO, LLC Company DEKO, LLC Russia

Manufacturer: & nbsp

Company DEKO, LLC Russia

Representation: & nbspCompany DEKO, LLCCompany DEKO, LLC

Information update date: & nbsp11.10.15

Illustrated instructions

Instructions

Vinpocetine (Vinpocetine)