Yodantipyrine - instructions for use, dose, side effects, contraindications

Active substanceIodofenazoneIodofenazone

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Yodantipyrine

pills inwards

Science Technics Medicine, LLC Russia

Yodantipyrine

pills inwards

UPDATE OF PFC, CJSC Russia

Dosage form: & nbsppills

Composition:

For one tablet:

Active substance: Iodofenazone - 100.0 mg.

Excipients: potato starch 26.0 mg, dextrose monohydrate 29.0 mg, low molecular weight povidone (low molecular weight polyvinylpyrrolidone) 5.0 mg, stearic acid 1.0 mg.

Description:

Tablets are white or almost white in color, odorless or with a weak specific odor, flat-cylindrical shape, with a bevel.

Pharmacotherapeutic group:Antiviral agent

ATX: & nbsp

J.05.A.X Other antiviral drugs

Pharmacodynamics:

Iodantipyrin® has anti-inflammatory, immunostimulating and interferonogenic properties. Stabilizes biological membranes and delays the penetration of the virus into the cell. It is an active inducer of alpha and beta interferon, stimulates cellular and humoral immunity. It is active against tick-borne encephalitis virus.

Pharmacokinetics:

Quickly absorbed from the gastrointestinal tract, bioavailability is 80%. Up to 95% is metabolized in the liver. Urinary excretion through the kidneys by active transport to the renal tubules: 3-5% unchanged, 80-90% inactive metabolites. Has a high affinity for tissue proteins. Binding to blood proteins is 25%.Half-life is about 6 hours.

Indications:

Prophylaxis of tick-borne encephalitis in adults, including emergency prophylaxis after tick sucking.

Contraindications:

Individual intolerance of Iodantipirin® and other iodine-containing drugs, hyperthyroidism, marked violations of liver and kidney function, pregnancy and lactation, children's age.

Dosing and Administration:

Yodantipirin® tablets take inside after eating.

a) after sucking on the mite:

300 mg (3 tablets) - 3 times a day for the first 2 days; 200 mg (2 tablets) - 3 times a day for the next 2 days; 100 mg (1 tablet) - 3 times a day for the next 5 days.

b) during the stay in places related from possible sucking of ticks:

200 mg (2 tablets) 1 time per day for the entire period; 200 mg (2 tablets) 3 times a day for 2 days before visiting places associated with possible sucking on ticks.

Side effects:

The drug is low-toxic, well tolerated.

In some cases possible diarrheal phenomenon, skin rash, itching, angioedema and other allergic reactions.When discontinuation of the drug, these phenomena disappear.

If any adverse reaction develops, consult a doctor as soon as possible. If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

To prevent an overdose, you must strictly follow the dosing regimen.

According to the indications - symptomatic therapy.

Interaction:Antacid preparations and antagonists H₂-receptors reduce the absorption of the drug. When combined with oral hypoglycemic drugs, barbiturates, tricyclic antidepressants, anticoagulants of indirect action, Yodantipirin® enhances their action, displacing them from the bond with proteins.

Special instructions:

It is not recommended to use joint application of Yodantipirin® and anti-malignant immunoglobulin.

Application of the drug Yodantipirin® for the prevention of tick-borne encephalitis is especially advisable:

- persons with contraindications to vaccination and use of immunoglobulin against tick-borne encephalitis, appointed for the purpose of specific prevention tick-borne encephalitis;

- persons who have previously completed a full vaccination against tick-borne encephalitis, as a additional preventive measures;

- when victims are treated late (after 3-4 days) after tick sucking, when the administration of human immunoglobulin against tick-borne encephalitis is not shown;

- in the absence of the possibility of a laboratory research mite or blood tests immunoassay method (for detection of tick-borne encephalitis virus antigen) in situations where the patient is in an area remote from specialized medical institutions or on the basis of a medical and preventive institution where the diagnosis of tick-borne infections is not established.

Form release / dosage:Tablets of 100 mg.

Packaging:

10 tablets per contour cell or cell-free packaging.

50 tablets per can of polymer.

1, 2 or 5 contour cell or non-jawed packages, each polymer can, along with the instruction for medical use, is placed in a pack of cardboard.

For 1000 contour non-jammed packages along with instructions for medical use are placed in boxes of corrugated cardboard (for hospitals).

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002505

Date of registration:16.09.2011 / 20.04.2016

Expiration Date:Unlimited

The owner of the registration certificate:Science Technics Medicine, LLCScience Technics Medicine, LLC Russia

Manufacturer: & nbsp

PHARMSTANDART-TOMSKHIMFARM, OJSC Russia

Representation: & nbspPHARMSTANDART JSC PHARMSTANDART JSC Russia

Information update date: & nbsp28.11.2017

Illustrated instructions

Instructions

Yodantipyrine (Iodantipirin)