Yodilife (Iodilife)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

Each tablet contains:

Active substances:

potassium iodide (equivalent to iodide) - 0.262 mg (0.200 mg), folic acid - 0.400 mg; cyanocobalamin (vitamin B12 N crystalline) * - 0.002 mg.

Excipients: lactose monohydrate 40,189 mg, microcrystalline cellulose 55.0 mg, sodium carboxymethyl starch 1.0 mg, calcium stearate 1.029 mg; * - sodium citrate - 0.063 mg, citric acid - 0.021 mg, maltodextrin - 2.01 mg.

Description:Round biconvex tablets from pale yellow to dark yellow. Blotches of a darker color are allowed.
Pharmacotherapeutic group:Vitamin B + other drugs
ATX: & nbsp
  • B vitamins
    • Pharmacodynamics:

    Folic acid belongs to the vitamins of group B. In the body folic acid is reduced to tetrahydrofolic, which is involved in the synthesis of purines and pyrimidines, the exchange of choline, as a whole - in the metabolism of nucleic acids and proteins. This plays an important role in the formation of the central nervous system, which develops in humans on the 15-28th day after fertilization. Deficiency of folic acid causes the development of neural tube defects in the fetus.

    Vitamin B12 inside the cell exists in the form of two active coenzymes: methyl cobalamin and adenosyl cobalamin. Methylcobalamin is necessary for the work of methionine synthetase, which is involved in the metabolism of folic acid. This interaction of folic acid with cobalamin is necessary for the normal synthesis of purines and pyrimidines, and therefore DNA.With vitamin deficiency B12 or folic acid, the reduced synthesis of methionine and 8-adenosylmethionine disrupts many methylation reactions, the synthesis of proteins and polyamines.

    400 micrograms of folic acid is the minimum effective daily dose recommended by the Centers for Disease Prevention (US, UK and Australia) to healthy women as an additional daily intake to prevent the development of neural tube defects in the fetus. The recommended daily intake of vitamin A B12 is 2 micrograms.

    Iodine is the main element for the synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3) (the mass fraction of iodine in which is 65% and 59%, respectively). Thyroid hormones are necessary at all stages of life for the normal functioning of the central nervous system (CNS).

    Pharmacokinetics:

    Folic acid is rapidly absorbed in the jejunum, subject to reduction and methylation to 5-methyl-tetrahydrofolate. The maximum concentration in plasma is observed after 30-60 minutes.

    Intensively binds to plasma proteins.Penetrates through the blood-brain barrier, into the placenta and breast milk. It is excreted by the kidneys mainly in the form of metabolites. Vitamin B12 can be absorbed after its interaction in the stomach with the internal factor of the Castle, the glycoprotein, which is secreted by the parietal cells of the stomach. The maximum concentration in plasma is observed after 8-12 hours. As with folic acid, the vitamin B12 is subject to significant enteric-liver recirculation.

    The average half-life of the vitamin B12 is about 6 days. Part of the dose administered is excreted by the kidneys within the first 8 hours, although most of it is excreted with bile. 25% is excreted through the intestine. In addition, the vitamin B12 penetrates the placenta and is present in breast milk.

    Vitamin B12 it binds to a considerable extent with plasma proteins, the excess accumulates in the liver.

    Iodine has a good absorption. It is believed that the coefficient of intestinal absorption of iodine after the intake of water-soluble iodine salts (for example, potassium iodide) is 100%. The mechanism of intestinal absorption of iodine is not known.

    After completion of the absorption process iodine quickly spreads through the intercellular fluid. Iodine penetrates the placental barrier and is present in breast milk. Iodine is transported to other tissues (except for the thyroid gland tissue): the milk / salivary glands and the intestinal mucosa.

    The main part of iodine is excreted by the kidneys and a small amount with saliva, milk, sweat, bile and through the intestine.

    Indications:Prevention of deficiency of iodine, folic acid and vitamin B12 (cyanocobalamin) in women of childbearing age at the stage of pregnancy planning (at least 1 month before conception). Prevention of neural tube defects in the fetus in the first trimester of pregnancy.
    Contraindications:

    Increased individual sensitivity to the components of the drug, lactation period, children's age.

    The preparation contains lactose. Patients with hereditary intolerance to galactose, deficiency of lactase or impaired absorption of glucose or galactose, the drug is contraindicated.

    At a daily dose of more than 150 mg / day potassium iodide is contraindicated in patients with acute bronchitis, severe and latent hyperthyroidism.

    Carefully:With caution appoint the drug to patients with: gipokomplementemicheskim vasculitis, goiter or autoimmune thyroiditis, kidney disease, chronic hyperkalemia, active tuberculosis, epilepsy.
    Pregnancy and lactation:

    The drug is recommended for use during pregnancy.

    The components of the drug penetrate into breast milk. Since there is currently no data on the use of the drug during this period, the drug is not recommended for use during breastfeeding.

    Dosing and Administration:

    1 tablet a day, before meals.

    The course of preventive treatment in women of childbearing age at the stage of pregnancy planning is at least 1 month before conception and during the first trimester of pregnancy. Repeated courses on the recommendation of a doctor.

    Side effects:

    Disorders from the gastrointestinal tract: diarrhea, nausea, vomiting, bloating and abdominal pain, flatulence, metallic taste in the mouth and increased salivation.

    Disorders from the endocrine system: goiter, hyperthyroidism and hypothyroidism.

    Disorders from the cardiovascular system: vasculitis, periarthritis with fatal outcome.

    Immune system disorders: edema (including edema of the face and glottis).

    Diseases from the skin: itching, rash and erythema, urticaria, exanthema and angioedema.

    Violations of the blood and lymphatic systems: thrombocytopenic purpura.

    Other disorders: hypersensitivity, general malaise, signs and symptoms similar to serum sickness: fever, joint pain, lymphatic cyst formation and eosinophilia.

    Overdose:

    In case of overdose or accidental ingestion, immediately consult a doctor.

    Overdose Symptoms: metallic taste in the mouth, increased sensitivity of teeth and gums, increased salivation, irritation of the mucous membrane of the nasal cavity, sneezing, swelling of the eyelids (symptoms known as "iodism").

    In addition, with an overdose of the drug, severe headache, cough, pulmonary edema, impaired parotid and submandibular gland function, inflammation of the pharynx, larynx and tonsils, a mild skin rash at the seborrheal sites, and disorders of the gastrointestinal tract (diarrhea).

    In case of an overdose, stop taking the medication and consult a doctor. Treatment is symptomatic.

    Interaction:

    The drug Jodilife should not be taken in combination with methotrexate, pyrimethamine, triamperene, trimethoprim, because they act as antagonists of folic acid, inhibiting tetrahydrofolate reductase.

    Reception of the drug Jodilife in combination with antiepileptic drugs from the hydantoin group (phenytoin) can reduce the effect of the latter.

    Analgesics (with prolonged therapy), estrogens and oral contraceptives increase the need for folic acid.

    Antacids (including preparations of calcium, aluminum and magnesium), colestramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid. The simultaneous use of the drug with potassium-sparing diuretics can lead to a decrease in the elimination of potassium by the kidneys, as a result of which there will be a chance of severe chronic hyperkalemia.

    Concomitant intake of lithium and potassium salts can lead to hypothyroidism.

    Simultaneous use with antithyroid drugs can lead to increased hypothyroidism.

    Special instructions:
    It should be borne in mind that antibiotics can distort (give underestimated results) the results of analysis of the concentration of folic acid plasma and erythrocytes. In view of the influence of iodides on the thyroid gland, taking these medications can lead to a distortion of the results of thyroid function tests. Do not take a double dose of the drug if you missed the next appointment.
    Effect on the ability to drive transp. cf. and fur:The use of the drug does not affect the performance of potentially hazardous activities requiring special attention and quick reactions (vehicle management, working with moving mechanisms, dispatcher and operator work, etc.).
    Form release / dosage:Pills.
    Packaging:For 28 tablets in a blister of opaque PVC / PVDC / aluminum. 1 blister together with instructions for use in a cardboard box.
    Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:3 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-000184
    Date of registration:25.01.2011 / 11.07.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:Italfarmaco SpAItalfarmaco SpA Italy
    Manufacturer: & nbsp
    Representation: & nbspITF, LLCITF, LLCRussia
    Information update date: & nbsp18.11.2017
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