Children have a high risk of intoxication with iron preparations, life-threatening conditions can occur with the intake of 1 g of iron sulfate. Therefore, iron preparations should be stored out of the reach of children
Symptoms: with a random intake of the drug in very high doses, weakness, fatigue, paresthesia, pallor of the skin, cold sticky sweat, lowering of blood pressure, palpitations, acrocyanosis, abdominal pain,diarrhea with an admixture of blood, cyanosis, confusion, weak pulse, hyperthermia, lethargy, convulsive seizures, symptoms of hyperventilation, coma. Signs of peripheral vascular collapse appear within 30 minutes after administration; metabolic acidosis, convulsions, fever, leukocytosis, coma - within 12-24 hours; acute renal and hepatic necrosis - after 2-4 days.
Treatment: before the specific therapy should be taken to remove from the stomach is not yet absorbed drug (gastric lavage), milk intake, raw eggs. Specific therapy is carried out by the administration of deferoxamine inward and parenterally. In acute poisoning to bind iron, not yet absorbed from the gastrointestinal tract, inwardly 5-10 g deferoxamine (dissolve the contents of 10-20 ampoules in drinking water). To remove absorbed iron deferoxamine administered intramuscularly slowly, to children - 15 mg / h, to adults - 5 mg / kg / h (up to 80 mg / kg per day); with mild poisoning - intramuscularly to children 1 g every 4-6 h, adults - 50 mg / kg (up to 4 g per day). In severe cases, accompanied by the development of shock, intravenously administered drip in a dose of 1 g and conduct symptomatic therapy.
Hemodialysis is ineffective for excretion of iron, but can be used to accelerate the excretion of iron-deferoxamine complex, and can also be prescribed for oligo- and anuria. Possible peritoneal dialysis.
In severe intoxication appoint unitiol (sodium dimercaptopropanesulfonate) parenterally. Because of the possible formation of neurotoxic complexes, unitiol should be used with caution.