Clinical and pharmacological group: & nbsp

Detoxifying agents, including antidotes

Included in the formulation
  • Unithiol
    solution w / m PC 
  • Unithiol
    solution w / m PC 
    StatusPharm, LLC     Russia
  • Unithiol
    solution w / m PC 
  • Unithiol
    solution w / m PC 
  • Unithiol
    solution w / m PC 
    ELLARA, LTD.     Russia
  • Unithiol
    solution w / m PC 
  • Unitiol-Binergia
    solution w / m PC 
    BINERGIYA, CJSC     Russia
  • Unithiol-Ferein
    solution
    BRYNTSALOV-A, CJSC     Russia
  • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    ONLS

    АТХ:

    V.03.A.B   Antidotes

    Pharmacodynamics:
    Detoxifying agent.
    Active sulfhydryl groups are associated with the formation of non-toxic water-soluble complexes with poisons in the blood and tissues, capable of interacting with sulfhydryl (thiol) groups of enzymes and inactivating them. Used as an antidote for poisoning with arsenic compounds and heavy metal salts.
    Pharmacokinetics:
    When parenteral administration is rapidly absorbed into the blood. Cmax is achieved 15-30 minutes after intramuscular injection. The half-life is 1-2 hours.After ingestion Cmax in the blood is achieved after 1.5 hours and is within 90-140 μg / ml. The magnitude of the apparent stationary volume of distribution is 166.5 μg / ml. Excreted by the kidneys, mainly as products of incomplete and complete oxidation, in part - in unchanged form.
    Strong binding of the drug with blockers of sulfhydryl groups and the rapid elimination of the complexes formed prevents the binding of thiol groups of enzymes and promotes the restoration of their activity, thereby weakening or completely eliminating the symptoms of poisoning. Increases the excretion of certain cations (especially copper and zinc) from metal-containing cell enzymes. In patients with diabetic polyneuropathy and secondary amyloidosis it helps to reduce pain syndrome, improve the state of the peripheral nervous system, normalize the permeability of capillaries.
    Indications:Acute and chronic poisoning by organic and inorganic compounds of arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony; intoxication with cardiac glycosides, hepatocerebral dystrophy (Wilson-Konovalov's disease), diabetic polyneuropathy,chronic alcoholism (as part of complex therapy), alcohol withdrawal syndrome.

    XIX.T51-T65.T65   Toxic effect of other and unspecified substances

    XIX.T51-T65.T56   Toxicity of metals

    XIX.T51-T65.T51   Toxic effect of alcohol

    VI.G60-G64.G63.2 *   Diabetic polyneuropathy (E10-E14 + with common fourth sign .4)

    Contraindications:Hypersensitivity, severe liver disease, hypertension.
    Carefully:Diseases of the liver, arterial hypertension.
    Pregnancy and lactation:If necessary, the use of the drug during pregnancy and lactation.
    Dosing and Administration:Inside, intramuscularly, subcutaneously.

    Poisoning with arsenic and mercury compounds: adults - intramuscularly, subcutaneously: 5-10 ml of 5% aqueous solution (at the rate of 0.05 g of the drug or 1 ml of 5% solution per 10 kg of body weight), in the first day 3-4 injections 6-8 hours), in severe cases - up to 8 injections; on the second day 2-3 injections (every 8-12 hours); in the next day 1-2 injections. Inside, 0.25-0.5 g per reception, if necessary, the dose can be increased to 0.75 mg per day in several doses. Children - intramuscularly, 1 ml of 5% solution per 10 kg of body weight, on the first day every 6 hours, the next day 1-3 injections. The duration of application depends on the rate of elimination of toxic compounds from the body.Treatment is carried out until the signs of intoxication disappear. When poisoning with salts of mercury, the injection is continued for 6-7 days.

    Intoxication with cardiac glycosides: intramuscularly, subcutaneously 5-10 ml of a 5% solution 3-4 times a day for the first two days, then 1-2 times a day until the cardiotoxic effect disappears; hepatocerebral dystrophy: intramuscularly 5-10 ml of 5% solution daily or every other day, course - 25-30 injections with a break between courses 3-4 months.

    Diabetic polyneuropathy: 5 ml 5% solution for 10 days or inside for 0.25 g for 10 days.

    Chronic alcoholism: intramuscularly, 3-5 ml 5% solution 2-3 times a week or inside 0.5 g 2-3 times a day.

    For relief of attacks of alcoholic delirium - intramuscularly, once 4-5 ml of a 5% solution.

    Side effects:
    Nausea, dizziness, tachycardia, pale skin.
    Allergic reactions are possible.
    Overdose:In the recommended doses and on the evidence of overdose phenomena does not arise.
    Interaction:The simultaneous use of sodium dimercaptopropanesulfonate with preparations containing heavy metals and alkalis is not recommended, since the rapid decomposition of sodium dimercaptopropanesulfonate occurs.
    Special instructions:In acute poisoning, along with the administration of the drug, gastric lavage, oxygen therapy, and glucose administration are performed.
    Instructions
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