Adrenalin (Adrenaline)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceEpinephrineEpinephrine
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  • Adrenalin
    solution for injections 
    MOSCOW ENDOCRINE FACTORY, FSUE     Russia
  • Adrenalin
    solution locally 
    MOSCOW ENDOCRINE FACTORY, FSUE     Russia
  • Adrenalin-SOLOfarm
    solution for injections 
    GROTEKS, LLC     Russia
  • Epinephrine hydrochloride-Vial
    solution for injections 
    VIAL, LLC     Russia
  • EPIDZHECT®
    solution w / m 
    Meda AB     Sweden
    • Dosage form: & nbsptopical solution
    Composition:

    1 ml of the solution contains:

    Active substance: adrenaline 1 mg

    Excipients: sodium chloride, sodium metabisulphite, chlorobutanol-hydrate, disodium ethylenediaminetetraacetic acid (edetate disodium), glycerol (glycerol), solution of hydrochloric acid 0,01 M.

    Description:

    Colorless or slightly colored transparent liquid with a characteristic odor.

    Pharmacotherapeutic group:Alpha- and beta-adrenomimetic
    ATX: & nbsp

    C.01.C.A.24   Epinephrine

    Pharmacodynamics:

    Alpha- and beta-adrenostimulating agent. At the cellular level, the effect is due to the activation of adenylate cyclase on the inner surface of the cell membrane, an increase in the intracellular concentration of the cyclic adenosine monophosphate and calcium ions.

    Acting on alpha-adrenergic receptors located in the skin, mucous membranes and internal organs,causes vasoconstriction, a decrease in the rate of absorption of local anesthetics, prolongs the duration and reduces the toxic effect of local anesthesia.

    Indications:Bleeding from the superficial vessels of the skin and mucous membranes, incl. from the gums.
    Contraindications:

    Hypersensitivity, hypertrophic obstructive cardiomyopathy, pheochromocytoma, arterial hypertension, tachyarrhythmia, ischemic heart disease, ventricular fibrillation, pregnancy, lactation.

    Carefully:

    Metabolic acidosis, hyperkonia, hypoxia, atrial fibrillation, ventricular arrhythmia, pulmonary hypertension, hypovolemia, myocardial infarction, shock of non-allergic genesis (including cardiogenic, traumatic, hemorrhagic), thyrotoxicosis, occlusive vascular diseases (including in anamnesis - arterial embolism, atherosclerosis, Buerger's disease, cold trauma, diabetic endarteritis, Raynaud's disease), cerebral atherosclerosis, angle-closure glaucoma, diabetes mellitus, Parkinson's disease, seizure syndrome, hypertrophy of the gland; simultaneous use of inhalation for general anesthesia (fluorotan, cyclopropane, chloroform), advanced age, children's age.

    Dosing and Administration:

    Locally: to stop bleeding in the form of tampons moistened with a solution of the drug.

    Side effects:

    From the cardiovascular system: less often - angina, bradycardia or tachycardia, palpitation, increase or decrease in blood pressure, at high doses - ventricular arrhythmias; rarely - arrhythmia, pain in the chest.

    From the nervous system: more often - headache, anxiety, tremor; less often - dizziness, nervousness, fatigue, psychoneurotic disorders (psychomotor agitation, disorientation, memory impairment, aggressive or panic behavior, schizophreniform disorders, paranoia), sleep disturbance, muscle twitching.

    From the digestive system: more often - nausea, vomiting.

    From the side of the urinary system: rarely - labored and painful urination (with prostatic hyperplasia).

    Allergic reactions: angioedema, bronchospasm, skin rash, erythema multiforme.

    Other: rarely - hypokalemia; less frequent - increased sweating
    Overdose:

    Symptoms: excessive increase in blood pressure, tachycardia, followed by bradycardia, rhythm disturbances (including atrial and ventricular fibrillation), cooling and pallor of the skin, vomiting, headache, metabolic acidosis, myocardial infarction, craniocerebral hemorrhage (especially in the elderly patients), pulmonary edema, death.

    Treatment: stop the use of the drug, symptomatic therapy - to reduce blood pressure - alpha-adrenoblockers (phentolamine), with arrhythmias - beta-blockers (propranolol).

    Interaction:

    Antagonists of epinephrine are blockers of alpha and beta-adrenergic receptors. Weakens the effects of narcotic analgesics and hypnotic drugs. When applied simultaneously with cardiac glycosides, quinidine, tricyclic antidepressants, dopamine, agents for inhalation anesthesia (chloroform, enflurane, halothane, isoflurane, methoxyflurane), the risk of arrhythmias increases with cocaine (together it should be used very carefully or not at all); with other sympathomimetic agents - increased severity of cardiovascular side effects; with antihypertensive agents (including diuretics) - reducing their effectiveness.

    Simultaneous administration with monoamine oxidase inhibitors (including furazolidone, procarbazine, selegiline) can cause a sudden and pronounced increase in blood pressure, hyperpyretic crisis, headache, cardiac arrhythmias, vomiting; with nitrates - weakening of their therapeutic effect; with phenoxybenzamine - increased hypotensive effect and tachycardia; with phenytoin - a sudden drop in blood pressure and a bradycardia; with preparations of thyroid hormones - mutual reinforcement of action; with drugs that extend QT-Interval (including astemisol, cisapride, terfenadine) - lengthening QT-Interval; with diatrizoates, iota-thalamic or yoxagolic acids - intensification of neurological effects; with alkaloids of ergot - increased vasoconstrictor effect (up to pronounced ischemia and development of gangrene).

    Reduces the effect of insulin and other hypoglycemic agents.

    Special instructions:

    Easily destroyed by alkalis and oxidizing agents.

    If the solution has become pinkish or brown or contains sediment, it can not be used. Unused portion should be destroyed.

    Form release / dosage:Topical solution 0.1%.
    Packaging:

    In bottles of 30 ml of light-protective glass with a screw neck with a stopper-dropper polyethylene and caps screwed on. One bottle with instructions for use in a pack of cardboard.

    Storage conditions:

    List B. In a place protected from light, inaccessible to children, at a temperature not exceeding 15 ° ะก.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-002714
    Date of registration:29.12.2006
    Expiration Date:19.12.2019
    The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia
    Manufacturer: & nbsp
    Information update date: & nbsp04.02.2017
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