Adjfluks - instructions for use, doses, side effects, contraindications

Excipients: Sucrose 40.0 mg, mannitol 282.5 mg, povidone 21.0 mg, sorbitol 16.0 mg, purified water q.s., sodium saccharinate 5.0 mg, isopropanol q.s.

Composition of lubricant: silicon dioxide colloid 8.0 mg, peppermint leaves oil 7.5 mg, magnesium stearate 20.0 mg.

Description:

Tablets are white with the possible presence of single dark inclusions, with mint odor, round, even on both sides.

Pharmacotherapeutic group:Antacid agent

ATX: & nbsp

A.02.A.X Antacids in combination with other drugs

Pharmacodynamics:

Combined product, the effect of which is due to its constituent components: antacid, adsorbing, enveloping action.Neutralizes free hydrochloric acid in the stomach, reduces the activity of pepsin, gastric juice, reduces the effect of damaging factors on the gastric mucosa. Does not cause secondary hypersecretion of gastric juice. Virtually not absorbed from the gastrointestinal tract. Evenly distributed over the gastric mucosa and provides long-lasting gastroprotection. The therapeutic effect is manifested in 3-5 minutes and lasts an average of 70 minutes.

Pharmacokinetics:

Absorption is low. If the correct dosage regimen and duration of treatment are observed, the drug is not practically absorbed from the gastrointestinal tract, does not disturb the electrolyte balance, and does not create the danger of the occurrence of alkalosis or other metabolic disorders.

Indications:

Acute gastritis, chronic gastritis with normal or increased secretory function in the exacerbation phase; acute duodenitis; peptic ulcer of the stomach and duodenum in the phase of exacerbation; erosion of the mucous membrane of the upper gastrointestinal tract; reflux esophagitis; hernia of the esophageal opening of the diaphragm; discomfort and epigastric pain,heartburn (after excess consumption of ethanol, nicotine, coffee, medication, inaccuracies in the diet).

Contraindications:

- Severe renal dysfunction;

- hypersensitivity to the components of the drug;

- children's age till 10 years;

- hypophosphatemia;

- Sucrose / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.

Carefully:

Diabetes mellitus, impaired renal function, Alzheimer's disease, pregnancy, lactation.

Pregnancy and lactation:

Use during pregnancy is possible if the potential benefit justifies the potential risk to the fetus.

When used according to the recommendations, aluminum absorption of hydroxide and magnesium salts is limited, so the drug is recognized as compatible with breastfeeding.

Dosing and Administration:

Inside, the tablets should be chewed or kept in the mouth until completely dissolved.

Adults the drug is prescribed for 2-3 tablets, 1-2 hours after meals and at night, with peptic ulcer of the stomach - 30 minutes before meals; if necessary, single dose increase to 3-4 tablets. After achieving the therapeutic effect - maintenance therapy 1 tablet 3 times a day for 2-3 months.

Children from the age of 10 1 tablet 1-2 hours after meals and at night, with stomach ulcer - 30 minutes before meals.

Side effects:

From the digestive system: constipation, diarrhea, nausea, vomiting, changes in taste.

From the immune system: hypersensitivity reactions (skin itching, hives, angioedema, anaphylactic reactions).

Other: with long-term admission in high doses - hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesia, hyperaluminia, encephalopathy, nephrocalcinosis, renal dysfunction.

In patients with concomitant renal failure - thirst, lowering blood pressure, hyporeflexia.

Overdose:

Symptoms: diarrhea, abdominal pain, vomiting.

Treatment: replenishment of fluid loss, forced diuresis. With renal failure - hemodialysis.

Interaction:

Reduces and slows the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H blockers₂-gistaminovyh receptors, beta-adrenoblokatorov; diflunisal, ketoconazole and itraconazole, isoniazid, tetracycline antibiotics and quinolones (ciprofloxacin, norfloxacin, ofloxacin,enoxacin, grapafloxacin, etc.), azithromycin, cefpodoxime, pivampicillin, rifampicin, indirect anticoagulants, barbiturates (they should be used 1 hour before 2 hours after taking antacids), fexofenadine, dipyridamole, zalcitabine, chenodeoxycholic and ursodeoxycholic acid, penicillamine and lansoprazole .

M-holinoblokatory, slowing the emptying of the stomach, strengthen and lengthen the action of the drug.

With simultaneous application with quinidine, it is possible to increase the serum concentrations of quinidine and the development of an overdose of quinidine.

When combined with polystyrene sulfonate (cayexalate), potassium binding may be reduced and metabolic alkalosis developed in patients with renal insufficiency and intestinal obstruction.

When combined with citrates, an increase in plasma concentrations of aluminum is possible, especially in patients with renal insufficiency.

Special instructions:

It should be observed a 2-hour interval between taking the drug Ajfluks and other medications.

At application it is necessary to provide sufficient receipt with food of salts of phosphorus.

When taking the drug Ajiflux tablets, patients with diabetes should take into account the sugar content in each tablet - 40.0 mg sucrose, which is less than 1 bread unit (XE).

Effect on the ability to drive transp. cf. and fur:

Does not affect the ability to drive a car and engage in other potentially dangerous activities that require increased attention and speed of psychomotor reactions.

Form release / dosage:Tablets are chewable.

Packaging:

For 10 tablets in a blister Al / PVC.

2 blisters together with instructions for use in a cardboard box.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000052

Date of registration:24.11.2010 / 31.03.2016

Expiration Date:Unlimited

The owner of the registration certificate:Agio Pharmaceuticals Ltd.Agio Pharmaceuticals Ltd. India

Manufacturer: & nbsp

AGIO PHARMACEUTICALS, Ltd. India

Representation: & nbspAgio Pharmaceuticals Ltd.Agio Pharmaceuticals Ltd.

Information update date: & nbsp09.02.2017

Illustrated instructions

Instructions

Agiflux (Agiflux)