Can adsorb some medicines, thereby reducing their absorption. Reduces and slows the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H2-histamine receptor blockers, beta-adrenoblockers, diflunisal, isoniazid,antibiotics of the tetracycline series, quinolones (ciprofloxacin, norfloxacin, ofloxacin, enoxacin, grapafloxacin, etc.), azithromycin, cefpodoxim, pivapicillin, rifampicin, indirect anticoagulants, barbiturates, fexofenadine, dipyridamole, zalcitabine, bile acids - chenodeoxycholic and ursodeoxycholic, penicillamine, iron preparations and lithium, quinidine, lansoprazole, mexiletine, ketoconazole.
With simultaneous reception with preparations coated with an enteric-coated shell, increased alkalinity of the gastric juice can lead to an accelerated disruption of the envelope and cause irritation of the stomach and duodenum.
M-holinoblokatory, slowing the emptying of the stomach, strengthen and lengthen the action of the drug.