Acryderm GK - instructions for use, doses, side effects, contraindications

active substances: betamethasone dipropionate in terms of 100% substance 0.064 g, equivalent to 0.05 g of betamethasone, gentamicin sulfate in terms of gentamycin 0.1 g, clotrimazole in terms of 100% substance 1 g;

Excipients: propyl parahydroxybenzoate (nipazole) 0.05 g, liquid paraffin (vaseline oil) 5 g, isopropyl myristate 1 g, petrolatum up to 100 g.

Description:

Translucent ointment is white or almost white.

Pharmacotherapeutic group:Glucocorticosteroid for topical use + antibiotic-aminoglycoside + antifungal agent

ATX: & nbsp

S.01.C.A.05 Betamethasone in combination with antimicrobials

Pharmacodynamics:

The combined preparation has anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) action.

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides, it acts bactericidal.

Gram-negative microorganisms are highly sensitive: Proteus spp. (indol-positive and indolotric), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin-resistant).

Sensitive: Enterococcus faecalis, Scrralia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp.

Resistant: Neisseria meningitidis, Treponema pallidum, anaerobic microbes: Streptococcus spp. (Besides Streptococcus pneumoniae), Enterococcus faecalis; Providencia rettgeri.

Betamethasone - glucocorticosteroid, has a local anti-inflammatory, anti-edematous, anti-allergic effect.

Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It acts due to a disruption in the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Has a wide range of action.

Active with respect to pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics:

When the drug is applied in therapeutic doses, the transdermal absorption of active substances into the blood is very low. When applied to the skin, the intensity of absorption of betamethasone depends on the state of the epidermal barrier (inflammation and skin diseases increase absorption).The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which can lead to an increased risk of systemic side effects.

Indications:

Simple and allergic dermatitis (especially complicated by secondary infection), diffuse neurodermatitis (including atopic dermatitis), limited neurodermatitis (in t, including simple chronic lichen), eczema, dermatomycosis (dermatophytosis, candidosis, multicolored lichen), especially when localization in the groin and large folds of the skin.

Contraindications:

Hypersensitivity to any of the components of the drug, skin tuberculosis, cutaneous manifestations of syphilis, chickenpox, herpes simplex, skin post-vaccination reactions, open wounds, children's age (up to 2 years).

Carefully:

Pregnancy (especially I trimester). Children age from 2 to 18 years.

Pregnancy and lactation:

During pregnancy (especially in the first trimester), local application of ointments in pregnant women is allowed only in cases where the intended benefit to the mother exceeds the potential risk to the fetus. In such cases, the use of the drug should be short and limited to small areas of skin.

It is not known whether the components of the drug are excreted in breast milk.Therefore, when prescribing Acriderm® GK ointment during lactation, it is recommended that breastfeeding cease.

Dosing and Administration:

Outwardly. Ointment is applied to the affected areas of the skin, lightly rubbing, a small amount 2 times a day. Duration of treatment is determined individually and depends on the nosological form and severity of the disease. With dermatomycosis stop, the average duration of treatment is 2-4 weeks.

If clinical improvement does not occur in the near future, it is necessary to clarify diagor change the treatment schedule.

Side effects:

Itching, burning, irritation, dry skin, folliculitis, hypertrichosis, steroid acne, hypopigmentation, allergic reactions.

When applying occlusive dressings - maceration, infection, skin atrophy, striae, sweating.

With prolonged treatment or application on a large surface - the development of systemic side effects: weight gain, osteoporosis, increased blood pressure, swelling, ulceration of the gastrointestinal mucosa, exacerbation of hidden foci of infection, hyperglycemia, agitation, insomnia, dysmenorrhea.

Overdose:

Symptoms: phenomena of hypercorticism.

Treatment: gradual withdrawal of the drug. Symptomatic therapy. If necessary - correction of electrolyte disturbances.

Interaction:

Interactions of the drug with other drugs have not been identified.

Special instructions:

Avoid contact with eyes.

When there is a stable bacterial or fungal microflora, it is necessary to cancel the drug and prescribe the appropriate therapy.

Due to the fact that in children the area of skin with respect to body weight is higher than in adults, and the epidermis is not developed enough, with external application of the drug it is possible to absorb proportionally more active substances and, consequently, there is a greater risk of development of systemic side effects . Use the drug in children should be as short as possible and with all precautions.

Form release / dosage:

Ointment for external use, 0.05% + 0.1% + 1%.

Packaging:

15 or 30 grams per lip aluminum.

Each tube together with the instruction for use is placed in a pack of cardboard.

Storage conditions:

At a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-001890/10

Date of registration:12.03.2010 / 12.08.2016

Expiration Date:Unlimited

The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia

Manufacturer: & nbsp

AKRIKHIN HFK, JSC Russia

Representation: & nbspAKRIKHIN OJSC AKRIKHIN OJSC Russia

Information update date: & nbsp03.07.2017

Illustrated instructions

Instructions

Acriderm® GK (Akriderm® GK)