Combined preparation for topical application.
Betamethasone
Has anti-inflammatory, antipruritic, anti-allergic, decongestant and vasoconstrictive. It prevents the accumulation of neutrophils on the skin, reducing inflammatory exudate and production of lymphokines, inhibits the migration of macrophages, reduces the processes of infiltration and granulation.
By inhibition of phospholipase A activity2 and reducing the release of arachidonic acid from the phospholipids of cell membranes reduces the production of leukotrienes and prostaglandins. Reduces the main substance of the connective tissue, weakening the exudative and proliferative processes in the skin. Inhibits cellular kinins, which have proteolytic activity.
Gentamicin
Antibiotic from the group of aminoglycosides. It binds to the 30S subunit of the ribosome of the bacterial cell and disrupts the movement of the ribosome along the RNA strands.It also changes the processes of reading the code of the RhK, which leads to the synthesis of functionally inactive proteins. Is able to disrupt the permeability of the cytoplasmic membrane of microorganisms. Has a bactericidal action type in a relationship Neisseria gonorrhoeae, including strains producing penicillinase.
Clotrimazole
Antifungal agent from the group of imidazoles of a wide spectrum of action. It changes the permeability of cell membranes, which leads to the lysis of fungi. Effective against yeast fungi of the genus Candida and dermatophytes. Has antimicrobial effect against Gram-positive (Streptococcus, Staphylococcus) and Gram-negative bacteria (Gardnerella vaginalis, Bacteroides spp.), as well as in relation to Trichomonas vaginalis, Corynebacterium minutissimum, Malassezia furfur.