Alexitol sodium (Alexitolum natrium)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antacids

Included in the formulation
АТХ:

A.02.A.B   Aluminum compounds

Pharmacodynamics:

Neutralization of hydrochloric acid of gastric juice, a decrease in the activity of the enzyme pepsin.

Pharmacokinetics:

The drug is not absorbed, only a small amount of aluminum is absorbed from the gastrointestinal tract. Elimination unchanged through the gastrointestinal tract.

Indications:

Gastric ulcer, duodenal ulcer, gastritis chronic and acute, with normal or increased secretory function of the stomach. Duodenitis, heartburn, including the hernia of the esophageal opening of the diaphragm.

ICD-10

XI.K20-K31.K25   Stomach ulcer

XI.K20-K31.K26   Duodenal ulcer

XI.K20-K31.K29   Gastritis and duodenitis

XVII.Q38-Q45.Q40.1   Congenital hernia of the diaphragm aperture

XVIII.R10-R19.R12   Heartburn

Contraindications:

Hypersensitivity; atozrast to 12 years.

Carefully:

Appendicitis; bleeding of the gastrointestinal tract; colostomy / ileostomy; ulcerative colitis; diverticulitis; chronic diarrhea.

Pregnancy and lactation:

Category Food and Drug Administration (US Food and Drug Administration) not determined. The use of antacids is considered safe, except for prolonged use in large doses. Adequate and well-controlled studies in humans have not been conducted, but there are data on such side effects of antacids, as hypercalcemia, hypo-, hypermagnesia,as well as increased tendon reflexes in the fetus and / or newborns, whose mothers took long-term aluminum, calcium or magnesium-containing antacids, especially in large doses. There were no animal studies.

Dosing and Administration:

Orally 360 mg tablets, 360-720 mg 4-6 weeks, maximum dose 5.76 g (16 tablets) for 24 hours. The maximum dosage should not exceed two weeks, for more than two weeks, a doctor's consultation is necessary.

Side effects:

From the digestive system: constipation, changes in taste, nausea, vomiting, diarrhea.

From the laboratory indicators: with prolonged use in high doses - an increase in the concentration of aluminum in the blood, hypophosphatemia, hypocalcemia, hypermagnesia,

From the urinary system: kidney failure; with prolonged admission in high doses - hypercalciuria, renal dysfunction, nephrocalcinosis. When taking on a background of kidney failure, it is possible to lower blood pressure, thirst, hyporeflexia.

Other: at long reception in high doses encephalopathy, an osteoporosis, an osteomalacia, allergic reactions are possible.

Overdose:

Not described, symptomatic treatment.

Interaction:

Blockers H2-receptors, ketoconazole, iron preparations, sodium fluoride, tetracyclines, phenytoin, holinoblokatory, mekamilamin - reduced absorption, due to which the effectiveness of these drugs is reduced.

Amphetamines, quinidine - decrease in excretion and increase in toxic effect.

Pancrelolipase - decreased efficiency.

Methenamine - oppression of transformation into formaldehyde alkalization of urine reduces its effectiveness; simultaneous appointment is not recommended.

Vitamins of the group D - Hypermagnia, especially in patients with chronic kidney disease.

The resin of sodium polystyrene-sulfonate is alkalosis.

Sucralfate is a risk of aluminum intoxication.

Fluoroquinolones - crystalluria, nephrotoxicity, with a joint admission control of urine and kidney status is necessary.

Salicylates - with simultaneous admission with the drug, excretion increases, dosage adjustment is necessary.

Ammonium chloride, ascorbic acid, potassium and sodium phosphate, racemetionine and other means, acidifying urine, - the effectiveness of these drugs decreases due to alkalinization of urine when taking an antacid.

Special instructions:

With prolonged admission, it is necessary to control magnesium, calcium and phosphate in the blood, and also to monitor the functional state of the kidneys. Taking maximum doses longer than two weeks is only under the supervision and supervision of a doctor.

Admission of antacids should be continued for a minimum of 4-6 weeks after all symptoms disappear and the ulcer heals. In case of taking the maximum doses, the duration should not exceed 2 weeks, further reception - after consultation of the doctor.

Instructions
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