Algealdrate + Benzocaine + Magnesium hydroxide (Algeldratum + Benzocainum + Magnesii hydroxydum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Antacids

Included in the formulation
  • Almagel® A
    suspension inwards 
    Balkanfarm - Troyan AD     Bulgaria
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    VED

    АТХ:

    A.02.A.X   Antacids in combination with other drugs

    Pharmacodynamics:

    This drug has antacid and local anesthetic properties. It also has an enveloping and adsorbing effect. Magnesium and aluminum ions neutralize the hydrochloric acid of gastric juice, thereby reducing its acidity, as well as reducing the activity of pepsin, raising the tone of the esophageal sphincter. Benzocaine has a local anesthetic effect by blocking sodium channels and reducing the permeability of neuronal membranes for sodium ions, increasing its permeability for potassium ions. Thus, depolarization of the membrane of neurons is inhibited and initiation and conduction of nerve impulses are blocked.

    Pharmacokinetics:

    Absorption is low, elimination occurs through the gastrointestinal tract.

    Indications:

    Diseases of the gastrointestinal tract associated with a violation of the normal secretory function and / or with a violation of the integrity of the gastrointestinal mucosa (ulcers, erosion, gastritis, etc.), for the treatment of diseases of the esophagus (reflux esophagitis, hernia of the esophagus of the diaphragm) .

    ICD-10

    XI.K20-K31.K21.0   Gastroesophageal reflux with esophagitis

    XI.K20-K31.K26   Duodenal ulcer

    XI.K20-K31.K25   Stomach ulcer

    XI.K20-K31.K29   Gastritis and duodenitis

    XI.K20-K31.K29.1   Other acute gastritis

    XI.K20-K31.K29.5   Chronic gastritis, unspecified

    XI.K40-K46.K44.9   Diaphragmatic hernia without obstruction or gangrene

    XI.K50-K52.K52.9   Non-infectious gastroenteritis and colitis, unspecified

    XVIII.R10-R19.R10.1   Pain localized in the upper abdomen

    XVIII.R10-R19.R12   Heartburn

    XVIII.R50-R69.R52.2   Another constant pain

    XX.Y40-Y59.Y42.0   Glucocorticoids and their synthetic analogs

    XX.Y40-Y59.Y45   Analgesic, antipyretic and anti-inflammatory agents

    XXI.Z70-Z76.Z72.4   Unacceptable food intake and bad eating habits

    Contraindications:

    Pregnancy; individual intolerance to the components of the drug; chronic kidney disease; Alzheimer's disease; low phosphate levels in the blood; the period of the newborn; lactation.

    Carefully:

    Appendicitis or suspicion of it, bleeding - gastrointestinal, rectal or unspecified localization, ulcerative colitis, colostomy, ileostomy, diverticulitis; chronic diarrhea.

    Pregnancy and lactation:

    This drug is not classified FDA. The drug for oral administration refers to the weakly toxic agents and does not have embryotoxic, teratogenic and mutagenic effects. In some cases, marked tendon reflexes were noted in newborns whose mothers took the drug for a long time. In addition, newborns are at risk of developing hypermagnesemia, especially when dehydrated, so prolonged use of the drug in pregnant and newborns is not recommended.

    Dosing and Administration:

    Dosage regimen is individual and is selected by the doctor. On average, the drug is taken at a dose of 1-3 teaspoons 3-4 times a day before meals and at night or 1-2 hours after meals.

    Children strictly according to the doctor's prescription: up to 10 years - 1/3 of the dose for adults, 10-15 years - 1/2 dose.

    The maximum daily dose is 16 dosing spoons, at this dose the duration of treatment is not more than 2 weekspruce.

    Before taking the vial should be shaken.

    Side effects:

    On the part of organs GIT: a violation of taste, nausea, vomiting, spasm, epigastric pain, constipation.

    From the side of metabolism: hypercalciuria, hypermagnesia, hypophosphatemia.

    Other: drowsiness, osteomalacia, dementia and swelling of the extremities (against chronic renal failure), allergic reactions.

    Overdose:

    In case of an overdose, side effects may increase, it is necessary to consult a doctor and stop taking the drug. Overdose of benzocaine: cyanosis, dyspnoea, dizziness. Treatment: symptomatic and intravenous injection of methylene blue.

    Interaction:

    The drug slows the absorption and effectiveness of many medicines, because changes acidity in the gastrointestinal tract and promotes rapid gastric emptying, with some preparations forms non-absorbable complexes. This refers to preparations of iron salts, tetracyclines, βadrenoblockers, phenothiazines, isoniazides, indometacin, ciprofloxacin, blocker H2-receptors, ketoconazole, cardiac glycosides, etc. Therefore, between the methods of the drug and the listed drugs, a 1-2 hour break is necessary.

    Citrate and ascorbic acid - increases the absorption of aluminum, possible intoxication.

    Cholinesterase inhibitors (antimiasthenic agents, demecaria, insecticides, neurotoxic in large quantities, isofluorophate, thiotepa, cyclophosphamide, ecotiopath) - may inhibit the metabolism of PABA esters and increase the toxicity of anesthetics (including benzocaine) at their high absorption.

    Non-narcotic analgesics strengthen the action of benzocaine.

    Sulfanilamides - joint use is not allowed, because: 1) under the influence of antacid agents, a decrease in the absorption of sulfonamides is possible; 2) as a result of hydrolysis of benzocaine, para-aminobenzoic acid (PABA) is formed, which on the chemical structure is close to sulfonamides and is their competitive antagonist. With the simultaneous use of benzocaine with sulfonamides, their antimicrobial effect is weakened.

    Special instructions:

    For effective treatment, individual dosing by a doctor is necessary.

    With prolonged use, it is necessary to control the concentration of aluminum, magnesium and phosphate ions in the blood. Benzocaine can influence the results of determining the function of the pancreas using bentiromide. The drug should be discontinued 72 hours before the test.

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