From the side of the blood and lymphatic system:
- infrequently: hemorrhages in the skin (ecchymosis), bleeding of the mucous membranes;
- rarely: increased bleeding time, thrombocytopenia;
- very rarely: blood dyscrasia (agranulocytosis, aplastic anemia, neutropenia and pancytopenia).
From the immune system:
- very rarely: anaphylactic reactions.
From the side of metabolism:
- often: increased serum cholesterol levels (especially with prolonged treatment and, possibly, high doses), weight loss;
- infrequently: hyponatremia, weight gain;
- rarely: syndrome of inadequate production of antidiuretic hormone;
- very rare: increased prolactin levels in the blood.
From the side of the central nervous system and the peripheral nervous system:
- often: insomnia, increased nervous excitability, anorgasmia, unusual dreams, decreased libido, dizziness, decreased muscle tone, paresthesia, sedation, tremor;
- infrequently: apathy, hallucinations, violations of orgasm in women, convulsive disorders;
- rarely: manic disorders, serotonin syndrome, neuroleptic malignant syndrome;
- very rarely: delirium, psychomotor agitation, extrapyramidal reactions (dystonia and dyskinesia), tinnitus.
From the sense organs:
- often: disorders of accommodation, mydriasis, visual impairment;
- very rarely: angle-closure glaucoma.
On the part of the respiratory and mediastinal organs:
- often: yawning.
From the cardiovascular system:
- often: arterial hypertension, sensation of "hot flashes" to the skin of the face;
- infrequently: tachycardia, hypotension, postural hypotension, collapse;
- very rarely: lengthening of the interval QT, ventricular fibrillation, ventricular tachycardia (including ventricular fibrillation).
From the digestive system:
- often: decreased appetite, constipation, nausea, vomiting;
- infrequently: bruxism (involuntary gnashing of teeth), changes in taste sensations, changes in liver function parameters;
- rarely: hepatitis;
- very rarely: diarrhea.
From the skin and subcutaneous tissue:
- often: sweating (including nocturnal);
- infrequently: dermatitis, alopecia, photosensitivity reactions;
- very rarely: erythema multiforme, Stevens-Johnson syndrome, itchy skin.
From the side of skeletal-muscular and connective tissues:
- very rarely: rhabdomyolysis.
From the side of the kidneys and the urinary tract:
- often: disorders of urination (most often intermittent urination);
- infrequently: urinary retention.
From the organs of the reproductive system, breast and milk glands:
- often: erectile dysfunction and ejaculation;
- infrequently: menometrorrhagia.
General violations and changes in the place of introduction:
- often: weakness.
The "cancellation" syndrome of the Alventa®: anxiety, agitation, confusion, diarrhea, dizziness, dry mouth, weakness, headache, noise in the head, insomnia, nausea, paresthesia, sleep disorders, sweating and vomiting is associated with a sudden discontinuation of the drug or a decrease in its dose. The incidence of the syndrome increases with higher doses and with a longer duration of use. These symptoms usually pass on their own, although they can persist for several weeks. Recommended when canceling the event® gradually reduce the dose and leave the patient under medical supervision. The time required for the complete cancellation of the Alventa® depends on the doses used, the duration of treatment and the individual characteristics of the patient.