Most of the side effects listed below depend on the dose. With long-term treatment, the severity and frequency of most of these effects is reduced, and there is no need to cancel therapy.
In order of decreasing frequency: frequent ≥ 1%, infrequent ≥ 0.1% - <1%, rare ≥ 0.01% - <0.1%, very rare <0.01%.
General symptoms: weakness, increased fatigue.
From the gastrointestinal tract: loss of appetite, constipation, nausea, vomiting, dry mouth, rarely hepatitis.
From the side of metabolism: increased serum cholesterol levels,decreased body weight; infrequent: changes in laboratory tests of liver function, hyponatremia, syndrome of insufficient secretion of antidiuretic hormone.
From the cardiovascular system: arterial hypertension, hyperemia of the skin; infrequent: postural hypotension, tachycardia.
From the nervous system: unusual dreams, dizziness, insomnia, increased excitability, paresthesia, stupor, increased muscle tone, tremor, yawning; infrequent: apathy, hallucinations, muscle spasms, serotonin syndrome; rare: epileptic seizures, manic reactions, as well as symptoms resembling malignant neuroleptic syndrome (CNS).
From the genitourinary system: violations of ejaculation, erections, anorgasmia, dysuric disorders (mainly - difficulties in the beginning of urination); infrequent: decreased libido, menorrhagia, urinary retention.
From the sense organs: disorders of accommodation, mydriasis, impaired vision; infrequent: a violation of taste.
From the skin: sweating; infrequent: reactions of photosensitivity; rare: erythema multiforme, Stevens-Johnson syndrome.
On the part of the hematopoiesis system: infrequent: hemorrhages in the skin (ecchymoses) and mucous membranes, thrombocytopenia; rare: prolonged bleeding time.
Hypersensitivity reactions: infrequent: skin rash; very rare: anaphylactic reactions.
After abrupt cancellation venlafaxine or a decrease in its dose can be observed: fatigue, drowsiness, headache, nausea, vomiting, anorexia, dry mouth, dizziness, diarrhea, insomnia, anxiety, increased irritability, disorientation, hypomania, paresthesia, sweating. These symptoms are usually mild and go untreated. Because of the likelihood of these symptoms, it is very important to gradually reduce the dose of the drug.