Most of the side effects listed below depend on the dose. With long-term treatment, the severity and frequency of most of these effects is reduced, and there is no need to cancel therapy.
In order of decreasing frequency: frequent (<1/10 and> 1/100); infrequent (<1/100 and> 1/1000); rare (<1/1000); very rare (<1/10000)
Common symptoms: weakness, fatigue, headache, abdominal pain, chills, fever.
From the gastrointestinal tract: loss of appetite, constipation, nausea, vomiting, dry mouth; infrequent: bruxism, reversible increase in activity of hepatic enzymes; rare: gastrointestinal bleeding; very rare: pancreatitis.
From the nervous system: dizziness, insomnia, agitation, drowsiness; frequent: unusual dreams, anxiety, confused state of consciousness, increased muscle tone, paresthesia, tremor; infrequent: apathy, hallucinations, myoclonus; rare: ataxia, speech disorders, including dysarthria, mania or hypomania (see section "Special instructions"), manifestations resembling neuroleptic malignant syndrome, convulsive seizures (see section "Special instructions"), serotonergic syndrome; very rare: delirium, extrapyramidal disorders, including dyskinesia and dystonia, tardive dyskinesia, psychomotor agitation / akathisia (see section "Special instructions").
From the side of the cardiovascular system: Arterial hypertension, widening of blood vessels (blood flow), heart palpitations; infrequent: orthostatic hypotension, syncope, tachycardia; Very rare: pirouette arrhythmia, lengthening of the interval QT, ventricular tachycardia, ventricular fibrillation.
From the sense organs: disorders of accommodation, mydriasis, impaired vision, tinnitus; infrequent: a violation of taste.
On the part of the hematopoiesis system: infrequent: hemorrhages in the skin (ecchymosis) and mucous membranes; rare: thrombocytopenia, prolonged bleeding time; very rare: agranulocytosis, aplastic anemia, neutropenia, pancytopenia.
From the skin: sweating, itching and rash; infrequent: reactions of photosensitivity, angioedema, maculopapular rashes, urticaria; rare: alopecia, erythema multiforme, Stevens-Johnson syndrome.
From the genitourinary system: violations of ejaculation, erections, anorgasmia; infrequent: decreased libido, menstrual irregularity, menorrhagia, urinary retention; rare: galactorrhea.
From the side of metabolism: increased serum cholesterol levels, weight loss; infrequent: hyponatremia, syndrome of insufficient secretion of antidiuretic hormone, violation of laboratory tests of liver function; rarely: hepatitis; very rare: increased prolactin levels.
Musculoskeletal system: arthralgia, myalgia; infrequent: muscle spasm; very rare: rhabdomyolysis.
Children the following side effects were observed: abdominal pain, chest pain, tachycardia, refusal of food, weight loss, constipation, nausea, ecchymosis, epistaxis, mydriasis, myalgia, dizziness, emotional lability, tremor, hostility and suicidal ideation.
After a severe withdrawal of venlafaxine or a decrease in its dose, fatigue, drowsiness, headache, nausea, vomiting, anorexia, dry mouth, dizziness, diarrhea, insomnia, anxiety, anxiety, disorientation, hypomania, paresthesia, sweating may be observed. These symptoms are usually mild and go untreated. Because of the likelihood of these symptoms, it is very important to gradually reduce the dose of the drug (like any other antidepressant), especially after taking high doses. The length of the period necessary to reduce the dose depends on the size of the dose, the duration of therapy, and the individual sensitivity of the patient.