Ramipril
From the cardiovascular system: reduction of blood pressure, orthostatic hypotension, orthostatic collapse, tachycardia, rarely - arrhythmia, palpitations, exacerbation of Raynaud's syndrome. In case of excessive decrease in blood pressure, mainly in patients with coronary heart disease and clinically significant narrowing of the cerebral vessels, myocardial ischemia (angina pectoris) and cerebral ischemia (possibly with dynamic cerebral blood flow disorder or stroke) may develop.
From the genitourinary system: development or strengthening of symptoms of renal failure, proteinuria, oliguria, interstitial nephritis, nephrotic syndrome, decrease in urine volume, gynecomastia, decreased potency, libido.
From the central nervous system: dizziness, headache, weakness, drowsiness, peripheral neuropathy (paresthesia), nervous excitability, anxiety, tremor, muscle spasm, mood disorders, apathy, when used in high doses - insomnia, anxiety, depression, ataxia, confusion, fainting.
From the sense organs: vestibular disorders, taste disorders (eg, metallic taste), smell, hearing and vision, blepharitis, dry conjunctiva, lacrimation, tinnitus.
From the digestive system: nausea, vomiting, diarrhea or constipation, epigastric pain, intestinal obstruction, flatulence, pancreatitis, hepatitis, cholestatic jaundice, cholecystitis (with cholelithiasis), liver dysfunction with hepatic insufficiency, melena, ileus, dry mouth, thirst, loss of appetite, stomatitis, glossitis, inflammation of the salivary glands.
From the respiratory system: "dry" cough, bronchospasm, dyspnea, rhinorrhea, rhinitis, sinusitis, pharyngitis, hoarseness, bronchitis, interstitial pneumonia, pulmonary embolism, pulmonary infarction, pulmonary edema.
Allergic reactions: skin rash, itching, urticaria, conjunctivitis, photosensitization, angioedema of the face, extremities, lips, tongue, throat and / or larynx, exfoliative dermatitis, multiforme exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome) , pemphigus, serositis, onycholysis, vasculitis, myositis, muscle weakness, myalgia, arthralgia, arthritis, eosinophilia.
Other: cramps, alopecia, shingles, hyperthermia, increased sweating.
Laboratory indicators: hypercritininemia, increased urea nitrogen levels, increased activity of "hepatic" enzymes, hyperbilirubinemia, hyperkalemia, hyponatremia, anemia, decreased hemoglobin and hematocrit concentration, neutropenia, thrombocytopenia, agronulocytosis, pancytopenia, hemolytic anemia, the appearance of antinuclear antibodies.
Influence on the fetus: impaired fetal function, decreased blood pressure (BP) of the fetus and newborns, impaired renal function, hyperkalemia, skull bones hypoplasia, oligohydramnia, limb contracture, deformity of the skull bones, hypoplasia of the lungs.
Hydrochlorothiazide
From the side of water-electrolyte and acid-base balance: hypokalemia and hypochloraemic alkalosis may develop (dry mouth, thirst, heart rhythm, mood and psyche change, cramps or muscle pain, nausea, vomiting, weakness, hypochloremic alkalosis may develop hepatic encephalopathy or hepatic coma), hyponatremia (confusion consciousness, convulsions, apathy, slowing down the process of thinking, fatigue, irritability), hypomagnesemia (arrhythmias).
On the part of the hematopoiesis system: agranulocytosis, thrombocytopenia, hemolytic and aplastic anemia, leukocytopenia, eosinophilia, neutropenia, pancytopenia.
From the cardiovascular system: arrhythmia, orthostatic hypotension, tachycardia.
From the digestive system: cholecystitis, pancreatitis, jaundice, diarrhea, sialadenitis, constipation, anorexia, epigastric pain.
From the side of metabolism: hypercholesterolemia, hypertriglyceridemia, hyperglycemia, glucosuria, hyperuricemia, hypercalcemia, exacerbation of gout.
From the central nervous system: depression, sleep disturbance, anxiety, paresthesia, confusion, dizziness.
From the sense organs: xanthopia, visual impairment.
From the genitourinary system: impaired renal function, decreased potency, interstitial nephritis.
Allergic reactions: skin rash, hives, purpura, necrotizing vasculitis, Stevens-Johnson syndrome, respiratory distress syndrome (pneumonitis, noncardiogenic pulmonary edema), toxic epidermal necrolysis, photosensitivity; anaphylactic reactions (up to the life threatening anaphylactic shock).
Other: hyperthermia, weakness.