The pharmacological action of bicalutamide can cause the following side effects:
Often (> 10%): gynecomastia (may persist even after discontinuation of therapy, especially if the drug is taken for a long time, tenderness of the mammary glands, "flushes" of blood to the face, decreased sexual desire, sexual dysfunction;
Often (≥1%, but <10%): diarrhea, nausea, transient increase in hepatic transaminase activity,cholestasis and jaundice (these changes in liver function were rarely estimated as serious, transient, completely disappeared or decreased with continued therapy or after withdrawal), itching, asthenia; when using the drug in a daily dose of 150 mg - alopecia or hair regrowth, weight gain.
Rarely (≥ 0.1%, but <1%): increased sensitivity reactions, including angioedema and urticaria, interstitial lung diseases; when using the drug in a daily dose of 150 mg - abdominal pain, depression, dyspepsia, hematuria.
Rarely (≥ 0.01%, but <0.1%): vomiting, dry skin (with the use of the drug in a daily dose of 150 mg, dry skin is often observed), liver failure, (the cause-and-effect relationship with bicalutamide is not established).
With the simultaneous use of bicalutamide and GnRH analogues, the following adverse events with a frequency of ≥ 1% can also be observed (a causal relationship with the administration of the drug has not been established, some of the noted side effects have been observed in elderly patients):
From the side of the cardiovascular system: heart failure, stenocardia, conduction disorders, including lengthening PR and QT intervals, rhythm disturbances, nonspecific changes in the ECG, increased blood pressure, myocardial infarction, syncope.
From the digestive system: gastric bleeding, anorexia, dry mouth, indigestion, constipation, flatulence, periodontal abscess, gastric / intestinal cancer.
From the nervous system: dizziness, headache, insomnia, anxiety, drowsiness, neuropathy.
From the respiratory system: shortness of breath, chest pain, cough, pharyngitis, bronchitis, pneumonia, rhinitis, bronchospasm, nosebleeds.
From the urinary system: nocturia, dysuria, urinary retention, swelling, frequent urination, hydronephrosis, infection.
On the part of the hematopoiesis system: anemia.
Dermatological reactions: alopecia, skin rash, increased sweating, hirsutism, dry skin, herpetic infection, skin cancer.
From the musculoskeletal system: myasthenia gravis, myalgia, convulsions, arthritis, joint contractures, bone pain, leg cramps.
From the laboratory indicators: hyperglycemia, increased activity of AP, hypercreatininaemia, hypercholesterolemia, hyperbilirubinemia.
Other: diabetes, polyuria, increased or decreased body weight, abdominal, breast, pelvic pain, sexual dysfunction, development of the tumor process, chills, dehydration, gout, cataract.