Undesirable effects are classified according to the frequency of their development: very often (≥ 1/10), often (≥ 1/100, <1/10), infrequently (≥ 1/1000, <1/100), rarely (≥ 1 / 10000, <1/1000), very rarely (<1/10000), unknown frequency - the available data are insufficient to estimate the frequency of the side effect.
From the side of the blood and lymphatic system: often anemia.
From the immune system: infrequently - hypersensitivity reactions, angioedema, hives.
From the nervous system: often - decreased libido, depression, dizziness *, drowsiness, headache **.
From the cardiovascular system: often - "tides" of blood to the face *, increased blood pressure **; unknown frequency - myocardial infarction (reported fatal cases) **, heart failure **.
On the part of the respiratory system, the organs of the thorax and the mediastinum: infrequently - Interstitial lung disease (reported cases with fatal outcome).
From the gastrointestinal tract: often - pain in the abdomen *, constipation *, dyspepsia, flatulence, nausea *, vomiting **.
From the liver and bile ducts: often - hepatotoxicity, jaundice, increased activity of "liver" transaminases (described cases were rarely evaluated as serious, transient, completely disappeared or decreased with continued therapy); rarely - hepatic insufficiency (it was reported about cases with a lethal outcome, a causal relationship with bicalutamide was not reliably established).
From the skin and subcutaneous tissues: Often - skin rash; often - alopecia, hirsutism / restoration of hair growth, skin rash **, dry skin, itchy skin.
From the side of the kidneys and urinary tract: often - hematuria *.
From the genitals and the breast: Often - gynecomastia and tenderness of the mammary glands (appeared in the majority of patients receiving bicalutamide monotherapy at a dose of 150 mg, in studies, these symptoms were found to be severe in 5% of patients and persisted after discontinuation of therapy, especially after prolonged therapy); often - erectile disfunction.
From the side of metabolism and nutrition: often - decreased appetite, weight gain, weight loss **.
Other: Often - asthenia; often - chest pain, swelling *, back pain **, flu-like syndrome **, increased alkaline phosphatase activity **, hyperglycemia **, arthralgia **.
* Side effects that occurred with simultaneous application of bicalutamide and GnRH analogues very often;
** side effects, which were noted only with simultaneous application of bicalutamide and GnRH analogues.