The pharmacological action of bicalutamide can cause the following side effects:
- very often (> 10%): gynecomastia (may persist even after cessation of therapy, especially if the drug is taken for a long time), soreness of the pancreas, "hot flushes";
- often (≥1% and <10%): diarrhea, nausea, transient increase in the activity of "liver" transaminases, cholestasis and jaundice (described changes in liver function were rarely evaluated as serious, transient, completely disappeared or decreased with continued therapy or after drug withdrawal), itching, asthenia; when using the drug in a daily dose of 150 mg - alopecia or hair regrowth, decreased sexual desire, sexual dysfunction, weight gain;
- rarely (≥0,1% - <1%): hypersensitivity reactions, including angioedema and hives, interstitial lung diseases; when using the drug in a daily dose of 150 mg - abdominal pain, depression, dyspepsia, hematuria;
- rarely (≥0,01% - <0,1%): vomiting, dry skin (with the use of the drug in a daily dose of 150 mg, dry skin is often observed), liver failure (the cause-and-effect relationship with bicalutamide is not established reliably).
With simultaneous application of Bicaluters and GnRH analogs, the following adverse events with a frequency of ≥ 1% can also be observed (a causal relationship with the drug intake has not been established, some of the noted side effects have been observed in elderly patients):
From the cardiovascular system: heart failure.
From the gastrointestinal tract: anorexia, dry mouth, indigestion, constipation, flatulence.
From the central nervous system: dizziness, headache, insomnia, increased drowsiness.
From the respiratory system: dyspnea
From the genitourinary system: sexual dysfunction, nocturia.
From the hematopoietic system: anemia.
From the skin and its appendages: alopecia, skin rash, excessive sweating, hirsutism.
Other: diabetes, hyperglycemia, increased or decreased body weight, abdominal pain, chest pain, pelvic pain, chills.